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首页> 外文期刊>African Journal of Cellular Pathology >HEMATOLOGICAL EVALUATION OF ABINO RATS ORALLY ADMINISTERED PYRETHROIDS FORMULATION
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HEMATOLOGICAL EVALUATION OF ABINO RATS ORALLY ADMINISTERED PYRETHROIDS FORMULATION

机译：亚比诺大鼠的血液学评估口服拟拟除虫菊酯配方

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Aim: This study was carried out to determine the effect of Mortein on some hematological parameters.Methods: Fifty adult Albino rats (150- 200g) were acquired from the animal house of the College of Health Sciences, Delta State University Abraka and placed into four groups. Groups 1- 3 contained 15 rats each, while 4 contained 5 rats. Groups 1-3 were further sub-divided into 3 sub-groups of 5 rats each. The rats in Groups 1-3 were treated with 3 different doses of M for 7, 21 and 40 days respectively while Group 4 was given water as placebo. The rats were later sacrificed and blood samples were collected for hematological analysis. The data generated were presented as mean and standard error of mean. Significant differences were obtained by One Way Analysis of Variance at (p ≤ 0.05) with the aid of SPSS version 21.Results: Significant decrease in total white blood cell count was observed in rats treated with M in dose and time-dependent manner when compared to rats of the control group. There was also a consequent time-dependent significant decrease (p ≤ 0.05) of lymphocyte, significant increase (p ≤ 0.05) of neutrophil and slight increase of monocyte when compared to the control. Subsequently, PCV significantly (p ≤ 0.05) reduced in treated rats compared to the control.Conclusion: Over exposure to the insecticide, Mortein reduces total white blood cells and packed cell volume.
机译：目的是进行该研究以确定Mortein对一些血液学参数的影响。方法：五十年代白果大鼠（150- 200g）从德塔州立大学亚伯拉卡省健康科学院的动物屋中获得，并分为四个团体。组1-3含有15只大鼠，而4只含有5只大鼠。将组1-3进一步分为3只大鼠的3个亚组。将组1-3中的大鼠分别用3种不同剂量的M，分别用3例M×21和40天处理，而第4组被给予水作为安慰剂。大鼠后来处死，并收集血液样品进行血液学分析。生成的数据作为平均值和标准误差呈现。借助于SPSS版本21，通过一种方式分析（P≤0.05）的一种方式分析了显着的差异。结果：在比较时用m以剂量和时间依赖方式处理的大鼠观察到总白细胞计数的显着降低对对照组的大鼠。随后的时间依赖性显着降低（P≤0.05）淋巴细胞，与对照相比，中性粒细胞的中性粒细胞显着增加（P≤0.05），单核细胞的轻微增加。随后，与对照相比，处理大鼠的PCV显着（p≤0.05）减少了处理的大鼠。结论：过度暴露于杀虫剂，Mortein减少了总白细胞和包装细胞体积。

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