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首页> 外文期刊>American journal of applied sciences >SIMULTANEOUS DETERMINATION OF AMLODIPINE AND ATORVASTATIN IN CADUET? TABLETS USING HPLC | Science Publications
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SIMULTANEOUS DETERMINATION OF AMLODIPINE AND ATORVASTATIN IN CADUET? TABLETS USING HPLC | Science Publications

机译：同时测定Caduet中氨氯堇和阿托伐他汀吗？使用HPLC的片剂|科学出版物

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摘要

> A simple, selective, sensitive and precise, simultaneous high performance liquid chromatographic analysis of tablets containing amlodipine and atorvastatin was described. Good chromatographic separation was achieved using a Perfectsilr Target ODS-3 (4.6 cm × 250 mm, 5 μm) and a mobile phase consisting of acetonitrile-phosphate buffer pH 4.5 (55:45, v/v) at a flow rate 1ML min-1. The ultraviolet detector was set at wavelength 237 nm. Amlodipine and atorvastatin were measured at 1.071 and 3.765 min, respectively. The linear ranges for amlodipine and atorvastatin were 1-10 and 5-50 μg mL-1, respectively. The recoveries of amlodipine and atorvastatin in pharmaceutical preparation were all greater than 98.5% and their relative standard deviations were less than 2.0%. The limits of detection were 0.19 and 1.25 μg mL-1 for amlodipine and atorvastatin, respectively.
机译：

描述了含氨氯地脂和阿托伐他汀的片剂的简单，选择性，敏感和精确，同时高效液相色谱分析。使用PerfectIilr靶ODS-3（4.6cm×250mm，5μm）和由乙腈 - 磷酸盐缓冲液pH 4.5（55:45，v / v）组成的流动率在流速1ml min < sup> -1 。紫外线检测器设定为波长237nm。在1.071和3.765分钟下测量氨氯地脂和阿托伐他汀。氨氯地平和阿托伐他汀的线性范围分别为1-10和5-50μgmL -1-sup>。药物制剂中氨氯地平和阿托伐他汀的回收率大于98.5％，其相对标准偏差小于2.0％。检测限为氨氯地脂和阿托伐他汀分别为0.19和1.25μgmL -1 -1 / sop>。

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