Carobomer Based Controlled Release Designs of Atorvastatin Calcium Tablets Evaluated Using Quality by Design (QbD) Approach

Arunkanth Krishnakumar Nair; Peddakotla Venkata Ramana; P. Venkat Bhaskar Rao; Bapatu Hanimi Reddy; Hari Kishan Reddy Ganthi; Useni Reddy Mallu

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Carobomer Based Controlled Release Designs of Atorvastatin Calcium Tablets Evaluated Using Quality by Design (QbD) Approach

机译：基于Carobomer的受控释放设计的阿托伐他汀钙片，通过设计（QBD）方法使用质量评估

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The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer. This system ensures the drug release at the alkaline pH region where the drug has got maximum solubility. Further the study was concentrated on comparing the impact of gelling agent polyvinyl pyrrolidone on drug release. Quality by design tools were considered during formulation development and the polymer concentrations were optimized adopting the statistical tool, design of experiments (DoE). The optimized formulation of present study exhibited desired controlled drug release characteristics in the alkaline pH conditions and at acidic environment the drug dissolution was minimal as intended.

机译：这里进行的研究主要用于使用Carbomer作为释放控制聚合物的甲吡伐素钙的常规单极控释基质片剂。该系统确保药物pH区域的药物释放，其中药物具有最大溶解度。此外，该研究浓缩了比较胶凝剂聚乙烯吡咯烷酮对药物释放的影响。在制剂开发期间考虑了设计工具的质量，并优化了聚合物浓度，采用统计工具，实验设计（DOE）。本研究的优化制剂在碱性pH条件下表现出所需的受控药物释放特性，并在酸性环境下，药物溶解如预期的最小。

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《American Journal of Analytical Chemistry》 |2017年第3期|共21页
作者
Arunkanth Krishnakumar Nair; Peddakotla Venkata Ramana; P. Venkat Bhaskar Rao; Bapatu Hanimi Reddy; Hari Kishan Reddy Ganthi; Useni Reddy Mallu;
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机译：基于设计的质量（QBD）基于数值和图形优化技术用于渗透泵控制释放的甲丙醇普胺HCL片剂的开发
7. Carobomer Based Controlled Release Designs of Atorvastatin Calcium Tablets Evaluated Using Quality by Design (QbD) Approach [O] . Arunkanth Krishnakumar Nair, Peddakotla Venkata Ramana, P. Venkat Bhaskar Rao, 2017

机译：基于Carobomer的受控释放设计的阿托伐他汀钙片，通过设计（QBD）方法使用质量评估

Carobomer Based Controlled Release Designs of Atorvastatin Calcium Tablets Evaluated Using Quality by Design (QbD) Approach

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