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首页> 外文期刊>American Journal of Analytical Chemistry >High Resolution Mass Spectrometry Elucidation of Captopril’s Ozonation and Chlorination By-Products
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High Resolution Mass Spectrometry Elucidation of Captopril’s Ozonation and Chlorination By-Products

机译：高分辨率质谱阐明卡托普利的臭氧化和氯化副产物

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The article evaluated the degradation of the captopril in aqueous solution after ozonation and chlorination. The process was continuously monitored focusing on the identification, mass spectrometry and elucidation of its by-products by applying direct infusion and high performance liquid chromatography, electrospray ionization high resolution mass spectrometry, in the negative ion mode. The cytotoxicity of its by-products solutions were evaluated with 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. It was observed through that after 30 min of ozonation and chlorination, there was complete oxidation of captopril, i.e., 100% removal efficiency. At these conditions, the rate of mineralization, by total organic carbon, was only 7.63% for ozonation and 6.40% for chlorination, evidencing the formation of degradation by-products. Ten captopril by-products were identified and their respective chemical structures elucidations are proposed. The treated samples and their by-products were nontoxic to HepG2 cells by MTT assay.
机译：该物品评估了臭氧化和氯化后的水溶液中的卡托普利的降解。通过施加直接输注和高效液相色谱，电喷雾电离高分辨率质谱法在负离子模式下，连续监测该方法的重点监测鉴定，质谱和副产物的鉴定，质谱和阐明其副产物。用3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴铵（MTT）测定评价其副产物溶液的细胞毒性。通过在臭氧化和氯化30分钟后观察到，氧化物完全氧化，即100％去除效率。在这些条件下，通过有机碳的矿化率仅为17.63％，对氟化，氯化6.40％，证明了副产物的降解形成。鉴定了十个卡托普利副产物，并提出了各自的化学结构阐明。通过MTT测定，处理过的样品及其副产物对HepG2细胞无毒。

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