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首页> 外文期刊>American Journal of Perinatology Reports >Safety and Efficacy of Higher Order Multifetal Pregnancy Reduction: A Single-Center Retrospective Study
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Safety and Efficacy of Higher Order Multifetal Pregnancy Reduction: A Single-Center Retrospective Study

机译：高阶多功能减少的安全性和有效性：单中心回顾性研究

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Objective This research was aimed to study the safety and efficacy of higher order multifetal pregnancy reduction (MFPR). Study Design This was a retrospective study of patients from an academic maternity center between 2005 and 2015. We evaluated outcomes of 131 consecutive patients who underwent higher order MFPR (quadruplets and greater). MFPR was performed at 11 to 18 weeks of gestation in all cases. In total, 122 of 131 cases of higher order multiple pregnancy were reduced to twins. We discuss the perinatal outcomes of patients who underwent higher order MFPR, followed by a comparative analysis between the 122 cases of MFPR that were reduced to twins and 101 cases of nonreduced twin pregnancies. Results The study included 104 sets of quadruplets, 20 sets of quintuplets, 5 sets of sextuplets, 1 set of septuplets, and 1 set of octuplets. The perinatal outcomes of the 131 cases were as follows: pregnancy loss, preterm deliveries at 28 to 33 ( 6/7 ) weeks, and preterm deliveries at 34 to 36 ( 6/7 ) weeks occurred in 23.66, 9, and 37% of cases, respectively. The mean time of delivery was 36.56?±?1.77 weeks, and mean birth weight was 2,409.90?±?458.16?g, respectively. A total of 122 cases that were reduced to twins were compared with nonreduced twins. The pregnancy loss rate for reduced twins was significantly higher than that for nonreduced twins. The preterm labor rate, mean delivery week, mean birth weight, birth-weight discordance, incidence of gestational diabetes mellitus, and pregnancy-induced hypertension were not significantly different between the groups ( p ?0.05). Conclusion Perinatal outcomes were significantly improved by reducing the number of fetuses in higher order multifetal pregnancies. This study involved a large, diverse sample population, and the results can be used as a reference while conducting prenatal counseling.
机译：目的本研究旨在研究高阶多重妊娠减少（MFPR）的安全性和功效。研究设计这是2005年至2015年课程营养中心患者的回顾性研究。我们评估了131名连续患者的结果，接受了高阶MFPR（四轮节和更大）。在所有情况下，MFPR在妊娠的11至18周内进行。总共122例，131例高阶多次妊娠减少到双胞胎。我们讨论了经过高阶MFPR的患者的围产期结果，其次是122例MFPR之间的比较分析，减少到双胞胎和101例未制定的双胞胎妊娠病例。结果该研究包括104套四元平板，20套Quintuplet，5组Sextuplet，1组隔膜，1组Octuplets。 131例的围产期结果如下：妊娠损失，28至33例（6/7）周的早产递送，23.66,9和37％的34〜36个星期的早产递送病例分别。平均递送时间为36.56？±1.77周，平均出生体重分别为2,409.90？±458.16克。将共122例减少到双胞胎，与无重量的双胞胎进行比较。减少双胞胎的妊娠损失率明显高于未更新的双胞胎。早产劳动力率，平均分娩周，平均出生体重，孕术糖尿病发病率和妊娠诱导的高血压在组之间没有显着差异（p> 0.05）。结论通过降低高阶多次妊娠的胎儿数量，围产期结果显着提高。这项研究涉及大型，不同的样本群体，结果可以在进行产前咨询时作为参考。

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