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首页> 外文期刊>American Journal of Ophthalmology Case Reports >Periorbital botulinum toxin A improves photophobia and sensations of dryness in patients without migraine: Case series of four patients
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Periorbital botulinum toxin A improves photophobia and sensations of dryness in patients without migraine: Case series of four patients

机译：Periobital Botulinum Toxin A改善了噬菌体的噬菌体和无偏头痛的患者干燥的感觉：案例系列4名患者

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PurposeIndividuals receiving botulinum toxin A (BoNT-A) injections in the head and neck for migraine treatment have reported decreases in photophobia and sensations of dryness, independent of ocular surface parameters. We hypothesized that patients without migraine but with similar ocular neuropathic-like symptoms would also experience symptomatic improvement with periocular BoNT-A injections, independent of ocular surface changes.ObservationsWe identified four individuals without a history of migraine but with neuropathic ocular pain (symptoms of dryness, burning, and photophobia that were out of proportion to ocular surface findings and unresponsive to ongoing dry eye (DE) therapies). Individuals underwent 1 session of periocular BoNT-A injections. Validated questionnaires (Visual Light Sensitivity Questionnaire-8, Dry Eye Questionnaire-5) assessed photophobia and DE symptoms pre- and 1-month post-injections. All four reported improvements in frequency and severity of photophobia and eye discomfort following BoNT-A injections. Tear film parameters (phenol red thread test, tear break-up time, corneal staining, and Schirmer test) and eyelid (palpebral fissure height and levator palpebrae superioris function) and eyebrow (position) anatomy were also evaluated before and after injections. Despite a unanimous improvement in symptoms, there were no consistent changes in ocular surface parameters with BoNT-A injections across individuals.ConclusionsPeriocular BoNT-A shows promise in reducing photophobia and sensations of dryness in individuals with neuropathic-like DE symptoms without a history of migraine, independent of tear film, eyelid, or eyebrow parameters.
机译：接受肉毒杆菌毒素A（BONT-A）注射的偶然生命性在用于偏头痛治疗中的头部和颈部注射，所述镜片中的噬菌体和干燥的感觉减少，与眼表面参数无关。我们假设没有偏头痛但具有相似眼神病的症状的患者也会对围绕围绕的注射进行症状改善，与眼表面变化无关。在没有偏头痛的情况下鉴定了四个人，但具有神经性眼痛（干燥症状）燃烧，烧焦与眼表面调查结果不成比例，对持续的干眼（de）疗法无响应）。个人接受了1次围眼的围绕注射液。经过验证的问卷（视觉光敏感性问卷-8，干眼问卷-5）评估了噬菌体和症状预先注射后1个月。所有四个报告的频率和严重程度的改善在牙齿注射后的尖端和眼睛不适。在注射之前和之后，还在注射前后评估撕裂膜参数（酚红线试验，角膜染色时间，角膜染色和角膜染色和席石运动试验）和眉毛（位置）解剖学。尽管症状有一致的改善，但是在跨越各个中的呼吸器的呼吸器的呼吸器的呼吸器和偏头痛症状的症状中的噬菌体和感觉中没有一致的症状，仍然存在一致的症状。 ，独立于泪膜，眼睑或眉头参数。

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