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首页> 外文期刊>Aging cell. >Reduced caloric intake and periodic fasting independently contribute to metabolic effects of caloric restriction
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Reduced caloric intake and periodic fasting independently contribute to metabolic effects of caloric restriction

机译：减少的热量摄入和周期性禁食独立促进热量限制的代谢效应

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Caloric restriction (CR) has positive effects on health and longevity. CR in mammals implements time‐restricted (TR) feeding, a short period of feeding followed by prolonged fasting. Periodic fasting, in the form of TR or mealtime, improves metabolism without reduction in caloric intake. In order to understand the relative contribution of reduced food intake and periodic fasting to the health benefits of CR, we compared physiological and metabolic changes induced by CR and TR (without reduced food intake) in mice. CR significantly reduced blood glucose and insulin around the clock, improved glucose tolerance, and increased insulin sensitivity (IS). TR reduced blood insulin and increased insulin sensitivity, but in contrast to CR, TR did not improve glucose homeostasis. Liver expression of circadian clock genes was affected by both diets while the mRNA expression of glucose metabolism genes was significantly induced by CR, and not by TR, which is in agreement with the minor effect of TR on glucose metabolism. Thus, periodic fasting contributes to some metabolic benefits of CR, but TR is metabolically different from CR. This difference might contribute to differential effects of CR and TR on longevity.
机译：热量限制（CR）对健康和长寿具有积极影响。哺乳动物中的CR实现时间限制（TR）喂养，短时间喂养，然后长时间禁食。定期禁食，以TR或餐饮时间的形式，改善了新陈代谢而不会降低热量摄入量。为了了解减少食物摄入和周期性的相对贡献和捕捉到Cr的健康益处，我们对小鼠进行了比较Cr和Tr（不降低食物摄入量）的生理和代谢变化。 CR在时钟周围显着降低血糖和胰岛素，改善葡萄糖耐受性和胰岛素敏感性增加（是）。 TR降低血液胰岛素和胰岛素敏感性增加，但与CR相反，TR没有改善葡萄糖稳态。昼夜节食的肝脏表达受到两种饮食的影响，而CR的MRNA表达由CR显着诱导，而不是通过TR，这与TR对葡萄糖代谢的微小效果一致。因此，周期性禁食有助于Cr的一些代谢益处，但TR与Cr等离不同的不同。这种差异可能导致CR和TR对寿命的差异影响。

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