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首页> 外文期刊>American Journal of Zoology >Review on the Role of Viral Structural Proteins on the Pathogenecity of Newcastle Disease Virus in Chickens
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Review on the Role of Viral Structural Proteins on the Pathogenecity of Newcastle Disease Virus in Chickens

机译：病毒结构蛋白对鸡鸡新城疾病病毒致病性的作用综述

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Newcastle disease virus (NDV) is a member of the family Paramyxoviridae, genus Avulavirus has a nonsegmented negative-sense RNA genome consisting of six genes (3'-NP-P-M-F-HN-L-5'). The six viral structural proteins play crucial role for the pathoginecity of the Newcastle diseases virus. Fusion protein cleaved by host protease enzyme from the precursor F0 glycoprotein to active F1 and F2 which are responsible for cell fusion and allow the entry of the virus to the host cell. Fusion protein has long been recognized as the primary determinant of virulence for NDV. Haemagglutinin neuraminidase (HN) glycoprotein has both haemagglutinating and neuraminidase activities which are responsible for attachment of virus to the host cell receptors and receptor destroying activity. M protein is thought to regulate the balance between viral replication and transcription and inhibit host protein synthesis that result Newcastle disease virus pathogenicity. The viral replication complex which comprises nucleocapsid protein (NP), phosphoprotein (P) and large polymerase protein (L) enhance viral replication that increase viral virulence. These proteins in combination play key roles in the pathogenicity of NDV. The objective of this seminar is to review the importance of Viral structural proteins on pathegenicity of Newcastle disease virus in chickens. A number of techniques have been used to assessing and quantify the pathologenicity of ND viruses in vivo, such as the intracerebral pathogenicity index (ICPI), the intravenous pathogenicity index (IVPI) and the mean death time in eggs (MDT). Determining the molecular basis for pathogenicity and virulence is an important step in both diagnostics and research and helps to identify strains that are likely to cause severe disease and to control NDV which cause severe economic losses in the poultry industry worldwide. Farther investigation which provide a more complete understanding about the molecular basis or viral proteins that responsible for pathogencity of NDV and more effective preventive approach for the disease is recommended for the feature.
机译：Newcastle疾病病毒（NDV）是家庭Paramyxoviridae的成员，Avulavirus属的非术语负感RNA基因组成，由六个基因组成（3'-NP-P-M-F-Hn-L-5'）。六种病毒结构蛋白对新城疫病毒病毒的病理性起到至关重要的作用。通过从前体F0糖蛋白的宿主蛋白酶酶切割的融合蛋白至活性F1和F2，其负责细胞融合并允许病毒进入宿主细胞。融合蛋白长期被认为是NDV毒力的主要决定因素。 Haemagglutinin Neuraminidase（HN）糖蛋白具有血糖凝集和神经氨氨酸酶活性，其负责将病毒附着到宿主细胞受体和受体破坏活性。 M蛋白被认为调节病毒复制和转录之间的平衡，并抑制宿主蛋白质合成，结果是新宫疾病病毒致病性。病毒复合复合物包含核衣壳蛋白（NP），磷蛋白（P）和大型聚合酶蛋白（L）增强了增加病毒毒力的病毒复制。这些蛋白质组合在NDV的致病性中发挥关键作用。本次研讨会的目的是审查病毒结构蛋白对鸡鸡的新城疫病毒的群体的重要性。已经使用许多技术来评估和量化体内Nd病毒的病理性，例如脑内致病性指数（ICPI），静脉内致病性指数（IVPI）和卵中的平均死亡时间（MDT）。确定致病性和毒力的分子基础是诊断和研究的重要步骤，并有助于鉴定可能引起严重疾病和控制NDV的菌株，并在全球家禽行业导致严重的经济损失。更远的调查，提供了对疾病的分子基础或病毒蛋白质负责该特征的疾病的病原体的病毒蛋白质的更完全了解。

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