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首页> 外文期刊>Annals of General Psychiatry >White matter abnormalities of corpus callosum in patients with bipolar disorder and suicidal ideation
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White matter abnormalities of corpus callosum in patients with bipolar disorder and suicidal ideation

机译：双相障碍和自杀素患者中胼callosum的白质异常

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Although many studies have shown that the corpus callosum (CC) may play an important role in bipolar disorder (BD) and suicide, the pathophysiological mechanism of BD underlying suicidal behavior is still unclear. This study aimed to explore the relationship between the CC, and BD and suicidal ideation using diffusion tensor imaging (DTI). A total of 203 participants (47 BD patients with suicidal ideation, 59 with BD without suicidal ideation, and 97 healthy controls [HC]) underwent DTI scanning at a single site. We examined the white matter integrity of the CC in the three groups. A comparison among groups showed that BD patients with suicidal ideation had significant lower fractional anisotropy (FA) values than those of BD without suicidal ideation and HCs in the body and genu of the CC, and FA values of BD without suicidal ideation were significantly lower than those of HCs. However, in the splenium of corpus callosum, no difference was found between BD without suicidal ideation and HCs. Our findings add to the evidence suggesting that the CC plays a key role in BD with suicidal ideation, especially with respect to the role of the genu and body of the CC subserving emotion regulation.
机译：虽然许多研究表明，胼callosum（cc）可能在双相障碍（bd）和自杀中起重要作用，但Bd潜在的自杀行为的病理生理机制仍然尚不清楚。本研究旨在利用扩散张量成像（DTI）探讨CC和BD与BD和自杀式思想之间的关系。共有203名参与者（47名BD患者患有自杀素，59例，BD没有自杀式映射，97例健康对照[HC]）在单一部位进行DTI扫描。我们在三组中检查了CC的白质完整性。组之间的比较显示，患有自杀性肌瘤的BD患者具有显着的较低的分数各向异性（FA）值，而不是在没有自杀念头的BD和NU中的HC和Nu的HC，而BD的BD的FA值明显低于HCS的那些。然而，在胼um的脾脏中，BD之间没有发生差异而没有自杀素肌瘤和HC。我们的调查结果增加了证据表明，CC在BD中发挥着关键作用，特别是关于CC剥夺情绪调节的现代和身体的作用。

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