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首页> 外文期刊>Antioxidants >Green-Sustainable Recovery of Phenolic and Antioxidant Compounds from Industrial Chestnut Shells Using Ultrasound-Assisted Extraction: Optimization and Evaluation of Biological Activities In Vitro
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Green-Sustainable Recovery of Phenolic and Antioxidant Compounds from Industrial Chestnut Shells Using Ultrasound-Assisted Extraction: Optimization and Evaluation of Biological Activities In Vitro

机译：使用超声辅助提取的工业栗色壳的酚类和抗氧化剂化合物的绿色可持续复苏：在体外优化和评估生物活性

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Chestnut processing industry generates large amounts of by-products, including leaves, burs and shells that are a source of bioactive compounds. The purpose of this study was to establish an ultrasound-assisted extraction (UAE) of phenolic and antioxidant compounds from industrial chestnut shells. A central composite design (CCD) was conducted to analyze the effects of time (4–46 min) and temperature (34–76 °C) in the antioxidant activity (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric reducing antioxidant power (FRAP)) and total phenolic compounds (TPC) of chestnut shells extracts. The optimal extraction conditions were obtained at 70 °C for 40 min. The optimal extract was characterized regarding phenolic profile, radical scavenging capacity, and effects on intestinal and dermal cell lines. The optimal extract revealed high amounts of ellagic acid (40.4 μg/mg dw), followed by caffeic acid derivative (15.4 μg/mg dw) and epigallocatechin (15.3 μg/mg dw). Indeed, the extract exhibited the highest scavenging efficiencies against NO● (IC 50 = 0.1 μg/mL) and HOCl (IC 50 = 0.7 μg/mL) and did not conducted to a decrease on HaCaT and HFF-1 viability up to 100 μg/mL. Oppositely, a decrease on Caco-2 and HT29-MTX viability was observed. This study suggests that UAE could be a sustainable option to valorize chestnut shells as raw material for different industries.
机译：栗子加工行业产生大量的副产品，包括叶片，毛刺和贝壳，是生物活性化合物的来源。本研究的目的是建立来自工业栗色壳的超声辅助萃取（UAE）的酚类和抗氧化剂。进行中央复合设计（CCD），以分析抗氧化活性（2,2'-氮杂基团（3-乙基苯并噻唑啉-6-）中的时间（4-46分钟）和温度（34-76℃）的影响磺酸（ABTS），2,2-二苯基-1-富铬酰基（DPPH），以及还原抗氧化能力（FRAP）和栗子壳提取物的总酚类化合物（TPC）。在70℃下获得最佳提取条件40分钟。最佳提取物对酚类概况，自由基清除能力和对肠道和皮肤细胞系的影响表征。最佳提取物显示出大量的鞣花酸（40.4μg/ mg DW），其次是咖啡酸衍生物（15.4 μg/ mg dw）和epigallocatechin（15.3μg/ mg dw）。实际上，提取物对NO●（IC 50 =0.1μg/ ml）和Hocl（IC 50 =0.7μg/ ml）表现出最高的清除效率。没有对HaCAT和HFF-1的减少降低，可达100μg/ mL。相反，Caco-2和HT29-MTX活力WA减少S观察到。本研究表明，阿联酋可以成为可持续选择，使栗子壳作为不同行业的原料。

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