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Gellable silk fibroin-polyethylene sponge for hemostasis

机译：可胶凝丝素蛋白 - 聚乙烯海绵用于止血

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div class="hlFld-Abstract test" Traditional haemostatic materials generally have slow hemostasis rate and poor biocompatibility. This paper reports on the haemostatic properties and mechanism of silk fibroin (SF). SF-PEG sponge that could be solubilised and changed to gel form by blood was fabricated through mixing SF and polyethylene glycol (PEG, 1500?Da) followed by lyophilisation of the mixed solution. SF-PEG sponge, together with control samples of SF sponge (no PEG) and a commercially available haemostatic material, gelatine sponge, were subjected to the hemostasis tests using a liver trauma model of rabbit. The results showed that SF was superior to gelatine sponge in hemostasis time (136.17?±?62.27?s and 249.83?±?29.18?s) and blood loss (2.16?±?1.27?g vs. 4.97?±?1.44?g). Furthermore, in?vitro experiments indicated SF-PEG sol-gel transition promoted platelet adhesion and aggregation, as well as platelet-fibrinogen interaction. Therefore, except for the physical blocking of bleeding port due to PEG-induced SF fast gelation, SF might also have an impact on blood coagulation process, a phenomenon that has not been reported before. In conclusion, SF is a new type of haemostatic material that might be able to meet the requirements of speed, efficiency and biosafety in a variety of clinical applications.
机译：Div类=“HLFLD-摘要测试”>传统止血材料通常具有缓慢的止血率和差的生物相容性。本文报道了丝素蛋白（SF）的止血性质和机制。通过混合Sf和聚乙二醇（PEG，1500→DA），通过混合SF和聚乙二醇（PEG，1500〜DA）来制造可以溶解和改变为凝胶形式的SF-PEG海绵。随后使用混合溶液的冻干。使用兔兔的肝脏创伤模型对SF-PEG海绵（NO PEG）和市售的止血材料，明胶海绵的控制样品以及可商购的止血剂。结果表明，SF优于止血时间的明胶海绵（136.17？±62.27×62.27〜±29.18°S）和血液损失（2.16？±1.27？G与4.97？±1.44？ ）。此外，在体外实验中，表明SF-PEG溶胶 - 凝胶转变促进血小板粘附和聚集，以及血小板纤维蛋白原相互作用。因此，除了由于PEG诱导的SF快速凝胶化引起的出血口的物理阻塞，SF也可能对血液凝固过程产生影响，这是之前尚未报道的现象。总之，SF是一种新型的止血材料，可以在各种临床应用中满足速度，效率和生物安全的要求。

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