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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Diallyl disulphide-loaded spherical gold nanoparticles and acorn-like silver nanoparticles synthesised using onion extract: catalytic activity and cytotoxicity
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Diallyl disulphide-loaded spherical gold nanoparticles and acorn-like silver nanoparticles synthesised using onion extract: catalytic activity and cytotoxicity

机译：使用洋葱提取物合成的二烯丙基二硫基负载的球形金纳米颗粒和橡胶状银纳米颗粒：催化活性和细胞毒性

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Onion (Allium cepa) extract was used for the green synthesis of gold and silver nanoparticles. Each colloidal solution exhibited surface plasmon resonance, with a peak at 532?nm for gold nanoparticles and 391?nm for silver nanoparticles. Microscopic results confirmed the presence of spherical shapes. The X-ray diffraction pattern demonstrated a face-centered cubic structure. Both nanoparticles had negative zeta potentials and retained colloidal stability in cell culture medium. Catalytic applications were evaluated for 4-nitrophenol reduction and methyl orange degradation reactions by monitoring with UV-visible spectrophotometry. Furthermore, the nanoparticles demonstrated no significant cytotoxicity against human pancreas ductal adenocarcinoma cells (PANC-1) and human colorectal adenocarcinoma cells (HT-29). PEGylation and diallyl disulphide loading of the gold and silver nanoparticles meaningfully reduced the cell viability of both cell lines. Furthermore, diallyl disulphide loading resulted in more cytotoxicity against PANC-1 cells than against HT-29 cells. Additionally, the gold nanoparticles were more cytotoxic than the silver nanoparticles upon diallyl disulphide loading. Interestingly, after PEGylation and diallyl disulphide loading, the silver nanoparticles exhibited acorn-like shapes, while the gold nanoparticles retained spherical shapes. This result suggested that nanoparticles green-synthesised by onion extract have possibilities as nanocatalysts and drug delivery nanocarriers for catalytic and nanomedicine applications.
机译：洋葱（葱属CEPA）提取物用于金和银纳米粒子的绿色合成。每个胶体溶液表现出表面等离子体共振，峰值为532Ω·nm，用于金纳米颗粒和391〜NM用于银纳米颗粒。微观结果证实了球形的存在。 X射线衍射图案表明了面为中心的立方结构。两种纳米颗粒在细胞培养基中具有负Zeta电位和保留的胶体稳定性。通过用UV可见分光光度法监测，评价催化应用的4-硝基苯酚还原和甲基橙降解反应。此外，纳米颗粒对人胰腺导管腺癌细胞（PANC-1）和人结肠癌腺癌细胞（HT-29）没有显着的细胞毒性。金和银纳米颗粒的聚乙二醇化和二烯丙基二硫化物负载有意义地降低了两种细胞系的细胞活力。此外，二烯丙基二硫化物负荷导致对Panc-1细胞的细胞毒性而不是对HT-29细胞。另外，金纳米颗粒比银纳米颗粒在二烯丙基二硫化物负载下比银纳米颗粒更具细胞毒性。有趣的是，在聚乙二醇化和二烯丙基二硫化物负载之后，银纳米颗粒表现出橡子状形状，而金纳米颗粒保持球形形状。该结果表明，洋葱提取物的纳米颗粒用洋葱提取物具有纳米催化剂和药物递送纳米载体的可能性，用于催化和纳米胺类应用。

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