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Effect of adjusting the combination of budesonide/formoterol on the alleviation of asthma symptoms

机译：调整胚乳/蛋白质组合对哮喘症状的影响的影响

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The combination of budesonide + formoterol (BFC) offers the advantages of dose adjustment in a single inhaler according to asthma symptoms. We analyzed the relationship between asthma symptoms in terms of peak expiratory flow (PEF) and dose adjustment by the patient. Twenty-eight patients with asthma who used BFC for alleviation of their symptoms (12 men, 16 women; 60?years old) were instructed that the inhaled BFC dose could be increased to a maximum of 8 inhalations per day according to symptom severity. Patients measured and recorded PEF every morning and evening in their asthma diary along with their symptoms and the dose of drugs taken. Sixteen of the 28 patients increased their dose for asthma symptoms. The time to recovery from the asthma symptoms was significantly shorter when cough was the only symptom present compared with dyspnea or wheeze (1.4 vs. 5.3 or 6.6?days, p??0.05) and when they had only one symptom compared with two or three symptoms (1.3 vs. 5.7 or 10.5, p??0.01). The relationship between PEF (% of personal best) when the dose was increased (Y) and the days for the increased dose to achieve a PEF greater than PEF in the symptom-free state (X) was determined to be Y?=?-?0.591X?+?89.2 (r2?=?0.299, p??0.001). As a guide for increasing the BFC dose when patients with mild asthma have asthma symptoms, the dose should be increased when cough is present or PEF is decreased to 88.9% (i.e., X?=?0.5).
机译：Presonide + Formoterol（BFC）的组合根据哮喘症状提供了单个吸入器中剂量调节的优点。我们在峰值呼气流（PEF）和剂量调节方面分析了哮喘症状之间的关系。二十八名哮喘患者使用BFC减轻其症状（12名男子，16名女性; 60？岁），指示吸入的BFC剂量可以根据症状严重程度增加每天8个吸入量。患者每天早上和晚上测量PEF，哮喘日记以及症状和服用的药物剂量。 28名患者的十六款哮喘症状增加了它们的剂量。当咳嗽是与呼吸困难或喘息或1.4与5.3或6.6？天，P？<0.05）相比的唯一症状症状，哮喘症状从哮喘症状恢复明显较短，与两个或两个或多个症状相比，它们只有一种症状三种症状（1.3对5.7或10.5，p？<0.01）。当剂量增加（Y）时PEF（个人最佳百分比）的关系，并且增加剂量增加的天数大于症状 - 无症状状态（X）中的PEF（X）的PEF，则为Y？=？ - ？0.591x？+？89.2（r2？=？0.299，p？<0.001）。作为增加BFC剂量的指南，当患有轻度哮喘患者的哮喘症状时，当存在咳嗽或PEF减少到88.9％时，应增加剂量（即，X？= 0.5）。

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