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首页> 外文期刊>Annals of Indian Academy of Neurology >Tolosa–Hunt Syndrome: Long-Term Outcome and Role of Steroid-Sparing Agents
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Tolosa–Hunt Syndrome: Long-Term Outcome and Role of Steroid-Sparing Agents

机译：Tolosa-Hunt综合征：长期结果和类固醇备件代理的作用

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Background: Tolosa-Hunt Syndrome (THS) is one of the causes of cavernous sinus syndrome causing painful ophthalmoplegia. Literature on long-term outcome of this rare condition is scarce. Aims and Objectives: The aim is to study the recurrence and role of steroid-sparing agents in THS. Methodology: All cases of THS treated at a tertiary-level teaching hospital during a 10-year period were studied. Clinical and radiological profile, response to treatment and recurrences were noted. Results: A total of 44 cases were studied. The mean age was 49.5 years, Males constituted 23/44 (52%). The first symptom was pain in 90%. Ptosis with ophthalmoplegia was the most common deficit 29/44 (66%). Lesions confined to cavernous sinus 27/44 (61%) was the most frequent magnetic resonance imaging finding. All patients received steroids as the initial treatment and 15/44 (34%) received steroid-sparing agents. Follow-up ranged from 6 to 120 months (Mean 39 months). Two patients had alternative diagnosis of leptomeningeal malignancy and hypertrophic pachymeningitis on follow-up. Recurrences occurred in 18/37 (48.6%). Time for recurrence varied from 8 months to 7 years. (Mean 18 months). No clinical or radiological predictors for recurrence were identified. Patients who received steroid-sparing agents had a significantly lower recurrence 3/15 (20%) versus 14/26 (53.8%)P 0.034. Conclusions: Around 50% of patients with THS can have recurrence. Steroid-sparing agents appear to prevent recurrence. A prospective multicenter randomized controlled trial may help to evaluate the risk and benefits of steroid-sparing therapy and to identify any possible predictors for recurrence.
机译：背景：Tolosa-Hunt综合征（THS）是潜水术治疗疼痛的窦综合垂体的原因之一。关于这种罕见状态的长期结果的文献是稀缺的。目标和目标：目的是研究类固醇备件代理的复发和作用。方法论：研究了在10年期间在第三级教学医院治疗的所有案件。注意到临床和放射性概况，对治疗和复发的反应。结果：研究共44例。平均年龄为49.5岁，男性组成23/44（52％）。第一个症状疼痛90％。具有眼科动脉杆菌的皮疱疹是最常见的赤字29/44（66％）。限制在海绵窦27/44（61％）限制的病变是最常见的磁共振成像发现。所有患者均接受类固醇作为初始治疗，15/44（34％）接受类固醇备件。随访范围从6到120个月（平均39个月）。两名患者在随访时替代诊断百分症恶性肿瘤和肥厚性嗜毒疗养炎。收发发生于18/37（48.6％）。复发时间从8个月到7年之间变化。 （平均18个月）。没有识别出临床或放射性预测因子进行复发。接受类固醇保释剂的患者具有显着降低的复发3/15（20％），而14/26（53.8％）P <0.034。结论：大约50％的患者患者可以复发。类固醇备件似乎防止复发。潜在的多中心随机对照试验可能有助于评估类固醇滥本治疗的风险和益处，并确定任何可能的预测因子进行复发。

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