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首页> 外文期刊>Annals of Indian Academy of Neurology >Successful Treatment of Human Immunodeficiency Virus-Associated Highly Active Antiretroviral Therapy-Resistant Vacuolar Myelopathy with Intravenous Immunoglobulin
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Successful Treatment of Human Immunodeficiency Virus-Associated Highly Active Antiretroviral Therapy-Resistant Vacuolar Myelopathy with Intravenous Immunoglobulin

机译：用静脉内免疫球蛋白成功治疗人免疫缺陷病毒相关的高活性抗逆转录病毒治疗抗性真空髓病变

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摘要

For the first time, human immunodeficiency virus (HIV)-associated vacuolar myelopathy (VM) was detailed in an autopsy-based study of 89 cases in 1985. This condition is the most common cause for spinal cord lesions in HIV patients. VM's pathogenic mechanism remains unclear; however, it is assumed that the disease can be related to both, the direct neurotoxic impact of the HIV and HIV-induced activation of immunopathological processes in the central nervous system (CNS). Reviewed in this paper is a case where the VM presentation deteriorated drastically when treated with highly active antiretroviral therapy, and almost completely regressed after the patient received the intravenous immunoglobulin (IVIg) treatment. The considered case demonstrates the viability of IVIg treatment in patients with HIV-associated CNS pathology, particularly when autoimmune reactions are suspected. The results of placebo-controlled studies of IVIg in patients with HIV-associated myelopathy may give a reliable evaluation of IVIg use in this context.
机译：首次，人类免疫缺陷病毒（HIV） - 分配的真空髓病变（VM）在1985年的89例的尸检研究中详述。这种情况是HIV患者脊髓病变最常见的原因。 VM的致病机制尚不清楚;然而，假设该疾病可能与艾滋病毒和HIV诱导的免疫病理过程中的直接神经毒性影响有关，中枢神经系统（CNS）中的免疫病理过程的激活。本文审查是一种情况，其中VM呈现在用高度活跃的抗逆转录病毒治疗后急剧恶化，并且在患者接受静脉内免疫球蛋白（IVIG）处理后几乎完全退化。被审议的案例显示了IVIG治疗在艾滋病毒相关的CNS病理患者中的可行性，特别是当怀疑自身免疫反应时。 HIV相关髓病患者IVIG的安慰剂对照研究结果可以在这种情况下可获得可靠的IVIG使用评估。

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