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首页> 外文期刊>Indian Journal of Ophthalmology >Short-term outcome of botulinum neurotoxin A injection with or without sodium hyaluronate in the treatment of infantile esotropia—a prospective interventional study
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Short-term outcome of botulinum neurotoxin A injection with or without sodium hyaluronate in the treatment of infantile esotropia—a prospective interventional study

机译：肉毒杆菌神经毒素的短期结果，注射或没有透明质酸钠治疗婴儿辅脱喉 - 一种前瞻性介入研究

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Purpose: To compare the short-term outcome of botulinum neurotoxin A (BoNT-A) with or without sodium hyaluronate in the treatment of infantile esotropia (IE). Methods: In this tertiary care hospital-based prospective, interventional, non-randomized study on infants with IE below one year of age, 25 cases were enrolled in the sodium hyaluronate (SH) group to receive 2.5 U BoNT-A injection combined with SH in each medial rectus muscle (MR). Thirty patients were enrolled in the control group to receive 2.5 U BoNT-A injection with normal saline in each MR. The change in mean primary ocular deviation (POD) and complications were assessed at 2 weeks, 1 month, 3 months, and 6 months post injection. Mann–Whitney U test was used for non-parametric unpaired data. Chi-square test and Fisher's exact test were used to test for the strength of the association between the two categorical variables. Results: Satisfactory ocular alignment was achieved in 76% in SH group and 73% in the control group (P value = 0.80). While the change in mean POD was comparable (29.2 prism diopters [PD] vs 29.3 PD; P value = 0.65), the complication rates were significantly lesser in SH (16% vs 33.3%; P value = 0.14). Conclusion: BoNT-A combined with SH is equally effective with lesser complications as compared to botulinum toxin alone in the treatment of IE.
机译：目的：将肉毒杆菌神经毒素A（BONT-A）的短期结果与透明质酸钠进行比较，治疗婴儿斜视（IE）。方法：在本次护理医院的前瞻性，介入，介入，无随机化研究，IE低于一年后的婴儿，透明质酸钠（SH）组中注册了25例，以获得2.5 U响应 - 注射液与SH合并在每个内侧肌肉（MR）中。在对照组中注册了30名患者，以获得2.5 u un-A注射，在每个MR中与生理盐水一起注射。注射后2周，1个月，3个月和6个月评估平均主要眼偏差（POD）和并发症的变化。 Mann-Whitney U测试用于非参数化未配对数据。 Chi-Square测试和Fisher的确切测试用于测试两个分类变量之间的关联的强度。结果：令人满意的眼部取向在76％的SH组中实现，对照组73％（P值= 0.80）。虽然平均豆荚的变化相当（29.2棱镜屈光度[Pd] Vs 29.3 Pd; p值= 0.65），SH中的并发症率显着较低（16％Vs 33.3％; P值= 0.14）。结论：与SH相结合的盲肠同等效果与单独的肉毒杆菌毒素相比，同样效果较小的并发症在治疗IE的治疗中。

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