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首页> 外文期刊>Indian Journal of Medical and Paediatric Oncology >Cerebral sinus venous thrombosis in indian pediatric patients with acute lymphoblastic leukemia: Incidence, risk factors, and outcome
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Cerebral sinus venous thrombosis in indian pediatric patients with acute lymphoblastic leukemia: Incidence, risk factors, and outcome

机译：脑鼻窦静脉血栓形成急性淋巴细胞白血病：发病率，危险因素和结果

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Background: Cerebral sinus venous Thrombosis (CSVT) is a rare complication of acute lymphoblastic leukemia (ALL) treatment, with an incidence rate ranging from 1.1% to 2.9%. Steroids and L-asparaginase (LASP) are the major risk factors. Methods: The aim of this study was to find the incidence rate and risk factors for CSVT in our patients. Ninety-two pediatric ALL diagnosed and treated with ALL-Berlin–Frankfurt–Munster-95 protocol over a period of 5 years (2013–2017) were the subject of the study. Six (6.5%) patients developed CSVT during their therapy and were further analyzed. Results: Six (five males and one female) patients had a CSVT event. The mean age at presentation was 13.5 ± 4.1 years. CSVT event occurred during the induction/re-induction phase of chemotherapy. The superior sagittal sinus was the most frequent site of thrombosis. The timing of CSVT was related to using of LASP and steroids. High-risk disease was associated with an increased risk of thrombosis. Infection and dehydration were other important risk factors. No association was observed between the risk of CSVT and age, sex, immunophenotype, and white blood cell count. All the patients were treated with low-molecular-weight heparin and one patient developed heparin-induced thrombocytopenia. No death occurred due to CSVT. Conclusions: The Incidence of CSVT was 6.5% in our study which is significantly high but comparable with studies from other Asian countries. It is, therefore, important to be vigilant for the detection of CSVT during treatment of ALL and initiate the appropriate treatment to prevent adverse events.
机译：背景：脑窦静脉血栓形成（CSVT）是急性淋巴细胞白血病（全部）处理的罕见并发症，发病率范围为1.1％至2.9％。类固醇和L-天冬酰胺酶（LASP）是主要的危险因素。方法：本研究的目的是在患者中找到CSVT的发病率和风险因素。在5岁（2013-2017）的全部柏林 - 法兰克福 - Munster-95议定书中均诊断和治疗九十二个儿科（2013-2017）是该研究的主题。六（6.5％）患者在治疗过程中开发了CSVT，进一步分析。结果：六（五个男性和一名女性）患者有一个CSVT事件。介绍的平均年龄为13.5±4.1岁。 CSVT事件发生在化疗的感应/再诱导阶段。卓越的矢状窦是血栓形成最常见的血栓形成。 CSVT的时序与使用LaSP和类固醇有关。高风险疾病与血栓形成的风险增加有关。感染和脱水是其他重要的风险因素。在CSVT和年龄，性别，免疫表型和白细胞计数的风险之间没有观察到任何关联。所有患者均用低分子量肝素治疗，一名患者发育肝素诱导的血小板减少症。由于CSVT，没有死亡。结论：我们的研究中CSVT的发病率为6.5％，这是明显高但与其他亚洲国家的研究相比。因此，重要的是在治疗中检测CSVT并启动适当的治疗以防止不良事件的情况是重要的。

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