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首页> 外文期刊>Indian Journal of Medical and Paediatric Oncology >Immunohistochemical profile and distribution of Non-Hodgkin and Hodgkin lymphoma - An experience in a medical college hospital in Tamil Nadu
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Immunohistochemical profile and distribution of Non-Hodgkin and Hodgkin lymphoma - An experience in a medical college hospital in Tamil Nadu

机译：非霍奇金和霍奇金淋巴瘤的免疫组化型和分布 - 泰米尔纳德邦医学院医院的经验

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Context: The subtype distribution of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) shows distinct pattern across geographic regions. This study analyzes the subtype distribution of lymphomas based on the WHO 2017 Classification using immunohistochemistry (IHC) and also investigates the IHC profile of various lymphomas. Subjects and Methods: Fifty consecutive cases of lymphoma diagnosed in the department of pathology in a medical college hospital were included in the study. The cases were subcategorized using panels of IHC based on the light microscopic findings. Results: The ratio of NHL to HL was 4.5:1. B-NHL formed 78.5% (n = 32), while T-cell NHL formed 21.5% (n = 9). Among the B-NHL cases, small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) (34.4%) was the most common, followed by diffuse large B-cell lymphoma, NOS (DLBCL NOS) (31.2%), follicular lymphoma (FL) (25%), and then by Burkitt's lymphoma (BL) constituting 9.4%. Peripheral T-cell lymphoma, NOS (PTCL NOS) (14.1%) (n = 6) was the most common T-cell NHL, followed by angioimmunoblastic T-cell lymphoma (4.8%), and then by lymphoblastic lymphoma (T-LL) (2.4%). Among Hodgkin lymphomas, mixed cellularity (MC) accounted for 55.6% (n = 5), lymphocyte depleted type (LD) being 22.2%, while nodular lymphocyte predominant and lymphocyte rich type each constituted 11.1%. Conclusion: SLL/CLL was the most common lymphoma reported in the study followed by DLBCL which is different from the other Indian studies where DLBCL was most common. CD5 expression was noted in 21% of FLs. PTCL-NOS constituted the most common T-cell lymphoma and MC, the most frequent subtype of classical HL. Further replication studies including larger sample size will be needed to understand the difference in subtype distribution in our population.
机译：背景：非霍奇金淋巴瘤（NHL）和霍奇金淋巴瘤（HL）的亚型分布在地理区域显示出明显的图案。本研究分析了使用免疫组织化学（IHC）的2017年淋巴瘤的亚型分布，并研究了各种淋巴瘤的IHC曲线。学科和方法：在医学院医院病理部诊断出患病患者的五十次连续病例被纳入该研究。基于光学显微镜发现，使用IHC的面板分类该病例。结果：NHL至HL的比例为4.5：1。 B-NHL形成78.5％（n = 32），而T细胞NHL形成21.5％（n = 9）。在B-NHL病例中，小淋巴细胞淋巴瘤/慢性淋巴细胞白血病（SLL / CLL）（34.4％）是最常见的，其次是弥漫性大B细胞淋巴瘤，NOS（DLBCL NOS）（31.2％），滤泡淋巴瘤（ FL）（25％），然后由Burkitt的淋巴瘤（BL）构成9.4％。外周T细胞淋巴瘤，NOS（PTCL NOS）（14.1％）（N = 6）是最常见的T细胞NHL，其次是血管免疫细胞T细胞淋巴瘤（4.8％），然后通过淋巴细胞淋巴瘤（T-LL ）（2.4％）。在霍奇金淋巴瘤中，混合细胞（MC）占55.6％（n = 5），淋巴细胞耗尽型（LD）为22.2％，而结节淋巴细胞主要和淋巴细胞浓度均为11.1％。结论：SLL / CLL是该研究中报道的最常见的淋巴瘤，其次是DLBCL，其不同于其他印度研究，其中DLBCL最常见。在21％的杂志中注意到CD5表达。 PTCL-NOS构成最常见的T细胞淋巴瘤和MC，古典HL的最常见的亚型。需要进一步的复制研究，包​​括更大的样本量，以了解我们人群中亚型分布的差异。

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