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首页> 外文期刊>Indonesian Journal of Environmental Management and Sustainability: IJEMS >Effectiveness of Spirulina platensis Extract on Wound Area and TNF-a Levels on Blood: Experimental Studies In Wistar Rats Made Artificially by Vulnus Scissum and Infected by Staphylococcus aureus
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Effectiveness of Spirulina platensis Extract on Wound Area and TNF-a Levels on Blood: Experimental Studies In Wistar Rats Made Artificially by Vulnus Scissum and Infected by Staphylococcus aureus

机译：螺旋藻提取物对伤口面积和TNF-A水平的有效性：Wistar大鼠vistar腕表的实验研究用vistar腕表和金黄色葡萄球菌感染

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This research uses randomizedpost-test only control group design. Thirty-two (32) male Wistar rats with incised skin and infected with S. aureusdivided into 4 groups, namely the group given S.platensisextract at a dose of 500 mg / kgBB / day (X1) and a dose of 750 mg / kgBB / day (X2 ), the negative control group was given saline solution (C1), and the positive control group was given amoxicillin 150 mg / kg orally(C2). Wound area measurements were taken on day 14 and serum TNF-? levels were examined on day 14 using the ELISA method. Data analysis was performed with one way ANOVAtestand continued with Post Hoc Test LSD.The results showed mean size of wound closure on the 14th day in groups X1, X2, C1 and C2 is 8095.74; 6270.98;15502.69; 11475.20micrometer with p 0.001. The mean TNF-? serum levels in the 14th day of X1, X2, C1, and C2 groups were 270.75; 222.83; 1730.33; 385.75pg / ml with p 0.001. Post Hoc Test of wound area showed significant differences between groups. Post Hoc Test TNF-? levels showed significant differences between treatment groups X1 and X2 with group C1.Spirulina platensisextract 500mg / kgBB / day and 750 mg /kgBB/ day have the smallest wound area significantly and reduce TNF-? levels on blood.
机译：本研究使用随机化柱测试仅控制组设计。三十二（32）只（32）只雄性Wistar大鼠具有切割的皮肤，并用S. aureusdiveded成4组，即给定的S.Platensisextract以500mg / kgbb /天（x1）和750 mg / kgbb的剂量/天（X2），给予阴性对照组给予盐水溶液（C1），阳性对照组给予阿莫西林150mg / kg口服（C2）。伤口面积测量是在第14天和血清TNF-中进行测量使用ELISA方法在第14天检查水平。通过一种方式进行数据分析，并且通过HOC试验LSD进行一种方式进行。结果显示在X1，X2，C1和C2组中的第14天内伤口闭合的平均尺寸为8095.74; 6270.98; 15502.69; 11475.20micrometer，p <0.001。平均tnf-？ X1，X2，C1和C2组第14天的血清水平为270.75; 222.83; 1730.33; 385.75pg / ml，p <0.001。伤口区域的后HOC试验在组之间显示出显着差异。后HOC测试TNF-？水平在C1.Pirulina铂金替氏菌属组500mg / kgbb /天和750mg / kgbb /天具有显着性伤口区域，显着降低TNF-的缺点和750mg / kgbb /天之间的显着差异。血液的水平。

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