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首页> 外文期刊>International braz j urol >The hOGG1 Ser326Cys gene polymorphism and susceptibility for bladder cancer: a meta-analysis
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The hOGG1 Ser326Cys gene polymorphism and susceptibility for bladder cancer: a meta-analysis

机译：Hogg1 Ser326cys基因多态性和膀胱癌的易感性：Meta分析

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Objective: To assess the susceptibility of the hOGG1 genetic polymorphism for bladder cancer and evaluate the impact of smoking exposure. Materials and Methods: Articles included in PubMed, Medline and Springer databases were retrieved using the following key words: “human 8-oxoguanine DNA glycosylase”, “OGG”, “OGG1”, “hOGG1”, “genetic variation”, “polymorphism” , “bladder cancer”, and “bladder carcinoma” to Meta-analysis was performed to detect whether there were differences between the bladder cancer group and the control group about the distribution of genotypes of the hOGG1 gene. Results: The results showed that there are no significant associations between the hOGG1 326Cys polymorphism and bladder cancer: GG vs. CC (OR: 1.09, 95% CI: 0.85–1.40, p=0.480); GC vs. CC (OR: 1.05, 95% CI: 0.85–1.28, p=0.662); GG+GC vs. CC (OR: 1.04, 95% CI: 0.89–1.21, p=0.619); GG vs. GC+CC(OR: 1.02, 95% CI: 0.78–1.33, p=0.888); G vs. C (OR: 1.01, 95% CI: 0.91–1.13, p=0.818). In the smoker population, no significant associations between the hOGG1 326Cys polymorphism and bladder cancer were observed for all the models. However, individuals carrying the hOGG1 Cys326Cys genotype have increased risk for bladder cancer compared to those carrying the hOGG1 Ser326Ser genotype in the non-smoker Asian population. Conclusion: The hOGG1 326Cys polymorphisms aren't a risk factor for bladder cancer, especially in the smoker population. But GG genotype is a risk factor for bladder cancer to the non-smoker Asian population compared with CC genotype.
机译：目的：评估膀胱癌的HogG1遗传多态性的敏感性，评价吸烟暴露的影响。材料和方法：使用以下关键词检索包含在PubMed，Medline和Springer数据库中的物品：“人类8-氧代DNA糖基糖基酶”，“OGG”，“OGG1”，“HogG1”，“遗传变异”，“多态性”进行“膀胱癌”和“膀胱癌”对Meta分析进行进行，以检测膀胱癌组和对照组是否存在关于霍格1基因基因型分布的差异。结果表明，结果表明，霍格1326CYS多态性和膀胱癌之间没有显着的关联：GG与CC（或：1.09,95％CI：0.85-1.40，P = 0.480）; GC与CC（或：1.05,95％CI：0.85-1.28，P = 0.662）; GG + GC与CC（或：1.04,95％CI：0.89-1.21，P = 0.619）; GG与GC + CC（或：1.02,95％CI：0.78-1.33，P = 0.888）; g vs. c（或：1.01,95％ci：0.91-1.13，p = 0.818）。在吸烟者中，对于所有模型，观察到霍格1 326cys多态性和膀胱癌之间没有显着的关联。然而，携带HogG1 Cys326CYS基因型的个体对非吸烟者亚洲人口中携带霍格1 Ser326Ser基因型的那些有膀胱癌的风险增加。结论：Hogg1 326cys多态性不是膀胱癌的危险因素，特别是在吸烟者中。但与CC基因型相比，GG基因型是膀胱癌对非吸烟者亚洲人群的危险因素。

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