...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International braz j urol >The effect of AST/ALT (De Ritis) ratio on survival and its relation to tumor histopathological variables in patients with localized renal cell carcinoma
【24h】

The effect of AST/ALT (De Ritis) ratio on survival and its relation to tumor histopathological variables in patients with localized renal cell carcinoma

机译：AST / ALT（DE RITIT）比率对局部肾细胞癌患者患者存活率及其与肿瘤组织病理学变量的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

ABSTRACT Purpose To assess the relationship between De Ritis (aspartate aminotransaminase [AST]/Alanine aminotransaminase [ALT]) ratio and pathological variables and whether it is an independent prognostic factor. Materials and Methods We analyzed 298 consecutive patients who underwent radical or partial nephrectomy for non-metastatic renal cell carcinoma (RCC) between 2006 and 2015. The association between De Ritis ratio and pathological variables including tumor size, presence of renal vein invasion, vena cava invasion, renal capsule infiltration, Gerota fascia invasion, renal sinus involvement, renal pelvic invasion, angiolymphatic invasion, adrenal gland involvement, lymph node involvement, tumor necrosis, and Fuhrman's grade was tested. Multivariable Cox analysis was performed to evaluate the impact of this ratio on overall survival and cancer-specific survival. Results An increased preoperative De Ritis ratio was significantly associated with renal vein invasion, renal capsule infiltration and renal pelvis involvement (p<0.05) in non-metastatic RCC. On multivariate analysis we found that tumor size, Fuhrman grade and lymph node involvement were independent prognostic factors for cancer-specific survival. AST/ALT ratio had no influence on the risk of overall and cancer-specific survival. Conclusion An increased preoperative AST/ALT ratio had a significant association with renal vein invasion, renal capsule infiltration and renal pelvis involvement in patients with non-metastatic RCC. However, it does not appear to be an independent prognostic marker in non-metastatic RCC.
机译：摘要目的评估DE RITIT（天冬氨酸氨管胺酶[AST] /丙氨酸氨基氨基氨基酶[ALT]）比率和病理变量以及其是一种独立的预后因素。我们分析了2006年至2015年期间接受了非转移性肾细胞癌（RCC）的自由基或部分肾切除术的298名连续患者。DE ritis比和病理变量之间的关联，包括肿瘤大小，肾静脉侵袭，腔静脉侵袭，肾囊浸润，Gerota筋膜入侵，肾窦参与，肾盂侵袭，血管脊髓源性侵袭，肾上腺受累，淋巴结受累，肿瘤坏死和Fuhrman等级进行了测试。进行多变量的COX分析以评估该比率对整体存活和癌症特异性存活率的影响。结果术前术前术术肾源性显着与肾静脉侵袭，肾胶囊浸润和肾骨盆受累（P <0.05）术后显着相关。在多变量分析中，我们发现肿瘤大小，富尔曼等级和淋巴结受累是癌症特异性生存的独立预后因素。 AST / ALT比对整体和癌症特异性生存的风险没有影响。结论术前AST / ALT比具有显着与肾静脉侵袭，肾囊浸润和肾盂患者的非转移性RCC患者有显着关系。然而，它似乎并未成为非转移rcc的独立预后标志物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号