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首页> 外文期刊>International Journal of Electrochemical Science >Electrochemical Behaviour of Apoferritin Encapsulating of Silver(I) Ions and Its Application for Treatment of Staphylococcus aureus
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Electrochemical Behaviour of Apoferritin Encapsulating of Silver(I) Ions and Its Application for Treatment of Staphylococcus aureus

机译：银（I）离子包封的氨代丁蛋白的电化学行为及其治疗金黄色葡萄球菌的应用

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Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for several difficult-to-treatinfections in humans. Therefore, it is not surprising that other ways how to treat these bacteria arelooked for. Silver(I) ions and silver nanoparticles exhibited the highest antimicrobial activity againstMRSA but their transporting to the place of needs and in situ determination is an issue. The aim of thiswork was electrochemical determination of silver(I) ions using four types of modified carbon pasteelectrodes (CPEs) with different content of carbon nanoparticles. CPE made from expanded carbonwas the most sensitive one. Therefore, we optimized the experimental conditions as time ofaccumulation 60 s, deposition potential 0.5 V and 0.2 M acetate buffer, pH = 5.0 to obtain detectionlimit (3 S/N) of 5 nM for silver(I) ions. Further, we studied the encapsulation of silver(I) ions intoapoferritin as a possible way for transportation of these ions. Primarily we optimized the encapsulationconditions to prepare the most stable complex, which was subsequently utilized for treatment of S.aureus. Based on the results obtained it can be concluded that silver(I) ions remain enclosed in theapoferritin structure until decomposition of apoferritin by bacterial enzymatic apparatus occurs.
机译：耐甲氧西林金黄色葡萄球菌（MRSA）是人类难以治疗的几种难以治疗。因此，其他方式如何治疗这些细菌的其他方式并不令人惊讶。银（I）离子和银纳米粒子表现出最高的抗菌活性，而是对其运输到需求和原位测定的运输是一个问题。本文的目的是使用具有不同碳纳米粒子的四种改性碳转秒（CPES）的银（I）离子的电化学测定。 CPE由扩展的Carbonwas制成，最敏感的CPE。因此，我们优化了实验条件作为累计累计60s，沉积电位0.5V和0.2M醋酸盐缓冲液，pH = 5.0，得到5nm的染色（I）离子的染色碱（3 s / n）。此外，我们研究了银（I）离子的封装，作为运输这些离子的可能方法。主要是我们优化了包封条件以制备最稳定的复合物，随后用于治疗S.aureus。基于所得的结果，可以得出结论，银（I）离子保持封闭在素烧霉蛋白结构中，直至通过细菌酶促装置进行分解氨代丁蛋白。

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