...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Experimental Diabetes Research: Experimental Diabesity Research >Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population
【24h】

Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population

机译：高温甘油敏血症腰部表型和脂质积累产品：两种综合肥胖指标腰围和甘油三酯预测中国人口中的2型糖尿病

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose. To determine whether hypertriglyceridemic waist (HTGW) and high lipid accumulation product (LAP) preceded the incidence of type 2 diabetes mellitus (T2DM), and to investigate the interactions of HTGW and LAP with other components of metabolic syndrome on the risk of T2DM. Methods. A total of 15,717 eligible participants without baseline T2DM and aged 35 and over were included from a Chinese rural cohort. Cox proportional hazards regression models were used to estimate the association of HTGW and LAP with the incidence of T2DM, and the restricted cubic spline model was used to evaluate the dose-response association. Results. Overall, 867 new T2DM cases were diagnosed after 7.77 years of follow-up. Participants with HTGW had a higher hazard ratio for T2DM (hazard ratio (HR): 6.249, 95% confidence interval (CI): 5.199-7.511) after adjustment for potential confounders. The risk of incident T2DM was increased with quartiles 3 and 4 versus quartile 1 of LAP, and the adjusted HRs (95% CIs) were 2.903 (2.226-3.784) and 6.298 (4.911-8.077), respectively. There were additive interactions of HTGW (synergy index (SI): 1.678, 95% CI: 1.358-2.072) and high LAP (SI: 1.701, 95% CI: 1.406-2.059) with increased fasting plasma glucose (FPG) on the risk of T2DM. Additionally, a nonlinear ( nonlinear & 0.001) dose-response association was found between LAP and T2DM. Conclusion. The subjects with HTGW and high LAP were at high risk of developing T2DM, and the association between LAP and the risk of T2DM may be nonlinear. Our study further demonstrates additive interactions of HTGW and high LAP with increased FPG on the risk of T2DM.
机译：目的。为了确定高温甘油纤维腰（HTGW）和高脂质累积产品（LAP）是否先于2型糖尿病（T2DM）的发病率，并研究HTGW和LAP与代谢综合征其他组分的相互作用对T2DM的风险。方法。共有15,717名没有基线T2DM和35岁及以上的符合条件的参与者被列入中国农村队列。 Cox比例危害回归模型用于估计HTGW和膝部与T2DM发射的关联，并且使用受限制的立方样条模型来评估剂量 - 反应关联。结果。总的来说，867例新的T2DM病例在777年后续后诊断出来。 HTGW的参与者对T2DM的危险比（危险比（HR）：6.249,95％置信区间（CI）：5.199-7.511）进行了较高的危险比（危险比（HR）：6.249％：5.199-7.511）。入射T2DM的风险与四分位数3和4个与leap的4个，并且调整后的HRS（95％CIs）分别为2.903（2.226-3.784）和6.298（4.911-8.077）。 HTGW的添加相互作用（Synergy指数（Si）：1.678,95％Ci：1.358-2.072）和高圈（Si：1.701,95％Ci：1.406-2.059），随着风险的增加而增加的空腹血糖（FPG） T2DM。另外，在LAP和T2DM之间发现非线性（非线性<0.001）剂量 - 反应关联。结论。具有HTGW和高圈的受试者患T2DM的高风险，并且圈之间的关联和T2DM的风险可能是非线性的。我们的研究进一步证明了HTGW和高圈的添加剂相互作用，增加了FPG的T2DM的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号