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首页> 外文期刊>International Journal of Environmental Research and Public Health >Fumonisin B1 Toxicity in Grower-Finisher Pigs: A Comparative Analysis of Genetically Engineered Bt Corn and non-Bt Corn by Using Quantitative Dietary Exposure Assessment Modeling
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Fumonisin B1 Toxicity in Grower-Finisher Pigs: A Comparative Analysis of Genetically Engineered Bt Corn and non-Bt Corn by Using Quantitative Dietary Exposure Assessment Modeling

机译：吐蕃素B1毒性在种植者猪中：使用定量膳食暴露评估建模对转基因BT玉米和非BT玉米的比较分析

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In this study, we investigate the long-term exposure (20 weeks) to fumonisin B1 (FB1) in grower-finisher pigs by conducting a quantitative exposure assessment (QEA). Our analytical approach involved both deterministic and semi-stochastic modeling for dietary comparative analyses of FB1 exposures originating from genetically engineered Bacillus thuringiensis (Bt)-corn, conventional non-Bt corn and distiller’s dried grains with solubles (DDGS) derived from Bt and/or non-Bt corn. Results from both deterministic and semi-stochastic demonstrated a distinct difference of FB1 toxicity in feed between Bt corn and non-Bt corn. Semi-stochastic results predicted the lowest FB1 exposure for Bt grain with a mean of 1.5 mg FB1/kg diet and the highest FB1 exposure for a diet consisting of non-Bt grain and non-Bt DDGS with a mean of 7.87 mg FB1/kg diet; the chronic toxicological incipient level of concern is 1.0 mg of FB1/kg of diet. Deterministic results closely mirrored but tended to slightly under predict the mean result for the semi-stochastic analysis. This novel comparative QEA model reveals that diet scenarios where the source of grain is derived from Bt corn presents less potential to induce FB1 toxicity than diets containing non-Bt corn.
机译：在这项研究中，我们通过进行定量暴露评估（QEA）来研究种植者猪中的长期暴露（20周）到富马激酶B1（FB1）。我们的分析方法涉及源自转基因芽孢杆菌（BT）的FB1暴露的膳食比较分析的确定性和半随机模型，常规的非Bt玉米和蒸馏器的衍生自BT和/或/或脱蛋白的干燥粒非Bt玉米。既确定性和半随机的结果表明，BT玉米和非BT玉米之间的饲料中的FB1毒性不同的差异。半随机结果预测了BT晶粒的最低FB1暴露，其平均值为1.5mg FB1 / kg饮食，以及由非Bt晶粒和非BT DDG组成的饮食的最高FB1暴露，其平均为7.87mg FB1 / kg饮食;慢性毒理学初期关注的水平为1.0毫克FB1 / kg饮食。确定性结果紧密镜像，但趋于略微预测半随机分析的平均结果。这种新的对比QEA模型揭示了谷物来源来自Bt玉米谷物来源的饮食情景呈诱导FB1毒性的潜力比含有非Bt玉米的饮食。

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