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首页> 外文期刊>International Journal of Environmental Research and Public Health >Quality Matters: Systematic Analysis of Endpoints Related to “Cellular Life” in Vitro Data of Radiofrequency Electromagnetic Field Exposure
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Quality Matters: Systematic Analysis of Endpoints Related to “Cellular Life” in Vitro Data of Radiofrequency Electromagnetic Field Exposure

机译：质量问题：对射频电磁场暴露的“细胞生命”的终点系统分析

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Possible hazardous effects of radiofrequency electromagnetic fields (RF-EMF) at low exposure levels are controversially discussed due to inconsistent study findings. Therefore, the main focus of the present study is to detect if any statistical association exists between RF-EMF and cellular responses, considering cell proliferation and apoptosis endpoints separately and with both combined as a group of “cellular life” to increase the statistical power of the analysis. We searched for publications regarding RF-EMF in vitro studies in the PubMed database for the period 1995–2014 and extracted the data to the relevant parameters, such as cell culture type, frequency, exposure duration, SAR, and five exposure-related quality criteria. These parameters were used for an association study with the experimental outcome in terms of the defined endpoints. We identified 104 published articles, from which 483 different experiments were extracted and analyzed. Cellular responses after exposure to RF-EMF were significantly associated to cell lines rather than to primary cells. No other experimental parameter was significantly associated with cellular responses. A highly significant negative association with exposure condition-quality and cellular responses was detected, showing that the more the quality criteria requirements were satisfied, the smaller the number of detected cellular responses. According to our knowledge, this is the first systematic analysis of specific RF-EMF bio-effects in association to exposure quality, highlighting the need for more stringent quality procedures for the exposure conditions.
机译：由于研究发现不一致，射频电磁场（RF-EMF）在低暴露水平下可能讨论了可能的危险效果。因此，本研究的主要焦点是检测RF-EMF和细胞反应之间是否存在任何统计关联，考虑单独的细胞增殖和细胞凋亡终点，并且两者兼作一组“细胞生命”以增加统计力量分析。我们在1995 - 2014年期间搜索了有关PubMed数据库中的RF-EMF体外研究的出版物，并将数据提取到相关参数，例如细胞培养类型，频率，曝光持续时间，SAR和五个曝光相关质量标准。这些参数用于与所定义的终点的实验结果进行关联研究。我们确定了104条发表的文章，从中提取并分析了483种不同的实验。暴露于RF-EMF后的细胞反应与细胞系而不是原发性细胞显着相关。没有其他实验参数与细胞反应显着相关。检测到具有暴露条件质量和细胞反应的高度显着的阴性关联，表明满足质量标准要求越多，检测到的细胞反应的数量越小。根据我们的知识，这是对特定RF-EMF生物效应的第一次系统分析与曝光质量相关，突出了需要更严格的暴露条件的质量程序。

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