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首页> 外文期刊>International Journal of Environmental Research and Public Health >First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study
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First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study

机译：婴儿开发和环境研究中的第一个三个月邻苯二甲酸盐暴露和婴儿出生体重

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Phthalate exposure is widespread among pregnant women but whether it is related to fetal growth and birth weight remains to be determined. We examined whether first trimester prenatal phthalate exposure was associated with birth weight in a pregnancy cohort study. We recruited first trimester pregnant women from 2010–2012 from four centers and analyzed mother/infant dyads who had complete urinary phthalate and birth record data ( N = 753). We conducted multiple linear regression to examine if prenatal log specific gravity adjusted urinary phthalate exposure was related to birthweight in term and preterm (≤37 weeks) infants, stratified by sex. We observed a significant association between mono carboxy-isononyl phthalate (MCOP) exposure and increased birthweight in term males, 0.13 kg (95% CI 0.03, 0.23). In preterm infants, we observed a 0.49 kg (95% CI 0.09, 0.89) increase in birthweight in relation to a one log unit change in the sum of di-ethylhexyl phthalate (DEHP) metabolite concentrations in females ( N = 33). In summary, we observed few associations between prenatal phthalate exposure and birthweight. Positive associations may be attributable to unresolved confounding in term infants and limited sample size in preterm infants.
机译：邻苯二甲酸酯暴露是孕妇的普遍存在孕妇中，但是否与胎儿生长和出生体重有关，仍有待确定。我们检查了妊娠队列研究中先妊娠期产前暴露于孕季戊二醇酯暴露是否与出生体重相关。我们从2010-2012中招募了妊娠孕妇的孕妇，分析了患有完全尿的母亲/婴儿二元（N = 753）。我们进行了多元线性回归，以检查产前对数大的重力调整尿邻苯二甲酸盐暴露是否与术语和早产（≤37周）婴儿有关的婴儿，分层。我们观察到邻苯二甲酸单羧酸异壬酯（MCOP）暴露和术语术语中的出生体重增加，0.13千克（95％CI 0.03,0.23）之间的显着关联。在早产儿，我们观察到磷酸二乙酯（DeHP）代谢物浓度的二乙基己基磷酸酯和（n = 33）中的一种对数单位变化的产生0.49kg（95％的CI 0.09,0.89）。总之，我们观察到产前邻苯二甲酸盐暴露和出生之间的少数关联。积极的协会可能归因于术语婴儿的尚未解决的混淆和早产儿的样本量有限。

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