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首页> 外文期刊>International Journal of Environmental Research and Public Health >Effects of Asian Dust Particles on the Early-Stage Antigen-Induced Immune Response of Asthma in NC/Nga Mice
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Effects of Asian Dust Particles on the Early-Stage Antigen-Induced Immune Response of Asthma in NC/Nga Mice

机译：亚洲粉尘颗粒对NC / NGA小鼠哮喘早期抗原诱导的免疫应答的影响

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Asian dust (AD) can aggravate airway inflammation in asthma, but the association between AD and the development of asthma remains unclear. This study aimed to investigate the effects of AD on the early stage of antigen sensitization using a mouse model of asthma, as well as the role of leukotrienes (LTs) in antigen-induced airway inflammation potentiated by AD particles. NC/Nga mice were co-sensitized by intranasal instillation of AD particles and/or Dermatophagoides farinae (Df) for five consecutive days. Df-sensitized mice were stimulated with an intranasal Df challenge at seven days. Mice were treated with the type 1 cysteinyl LT (CysLT1) receptor antagonist orally 4 h before and 1 h after the allergen challenge. At 24 h post-challenge, the differential leukocyte count, inflammatory cytokines, and LTs in bronchoalveolar lavage fluid were assessed, and airway inflammation was evaluated histopathologically. AD augmented neutrophilic and eosinophilic airway inflammation with increased CysLTs and dihydroxy-LT in a mouse model of asthma. The CysLT1 receptor antagonist was shown to attenuate both neutrophilic and eosinophilic airway inflammation augmented by AD. Therefore, exposure to AD may be associated with the development of asthma and LTs may play important roles in airway inflammation augmented by AD.
机译：亚洲尘埃（广告）可以加剧哮喘中的气道炎症，但广告之间的关联和哮喘的发展仍不清楚。本研究旨在探讨广告对使用哮喘小鼠模型的抗原致敏早期的影响，以及白三烯（LTS）在AD颗粒增强的抗原诱导的气道炎症中的作用。通过鼻内滴注AD颗粒和/或皮肤病连续五天，通过鼻内滴注来共敏化NC / NGA小鼠。在七天内用鼻内DF挑战刺激DF敏化小鼠。在过敏原攻击后，用1型胱抑素（CyslT1）受​​体拮抗剂，在过敏原攻击后1小时，用1型胱扣（Cyslt1）受体拮抗剂治疗小鼠。在攻击后24小时，评估了支气管肺泡灌洗液中的差分白细胞计数，炎性细胞因子和LTS，并且通过组织病理学评估了气道炎症。哮喘小鼠模型中，AD增强中性粒细胞和嗜酸性嗜嗜酸性嗜嗜酸性嗜嗜酸性嗜嗜酸性嗜嗜酸性嗜嗜酸性嗜嗜酸性胆管炎症。 Cyslt1受体拮抗剂被证明通过广告增强中性粒细胞和嗜酸性气动通道炎症。因此，暴露于AD可能与哮喘的发育相关联，LTS可能在Ad AD增强的气道炎症中发挥重要作用。

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