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首页> 外文期刊>International Journal of Environmental Research and Public Health >Enhancement of Toxic Efficacy of Alkylated Polycyclic Aromatic Hydrocarbons Transformed by Sphingobium quisquiliarum
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Enhancement of Toxic Efficacy of Alkylated Polycyclic Aromatic Hydrocarbons Transformed by Sphingobium quisquiliarum

机译：鞘型Quisquiarum转化烷基化多环芳烃毒性毒性毒性的增强

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摘要

Alkylated polycyclic aromatic hydrocarbons (PAHs) are abundant in crude oils and refined petroleum products and are considered as major contributors to the toxicity of spilled oils. In this study, the microbial degradation of model (alkylated) PAHs (i.e., phenanthrene, 3-methylphenanthrene, 3,6-dimethylphenanthrene (36DMPhe), pyrene, and 1-methylpyrene (1MP)) by the bacterium Sphingobium quisquiliarum EPA505, a known degrader of PAHs, was studied. To evaluate the toxic potential of the metabolic products, reaction mixtures containing metabolites of 36DMPhe and 1MP were fractionated by high-performance liquid chromatography, and their effects on the luminescence inhibition of Aliivibrio fischeri were evaluated. Although the luminescence inhibition of 36DMPhe and 1MP at their solubility levels was not observed, inhibition was observed in their metabolite fractions at the solubility limit of their parent molecule. This indicates that initial biotransformation increases the toxicity of alkylated PAHs because of the increased solubility and/or inherent toxicity of metabolites. Qualitative analysis of the metabolite fractions suggested that mono-oxidation of the methyl group is the main metabolic pathway of 36DMPhe and 1MP.
机译：烷基化多环芳烃（PAHS）在原油和精制的石油产品中丰富，并且被认为是溢油毒性的主要贡献者。在该研究中，通过鞘鞘穗Quisquiriarum EPA505的微生物（即，烷基化）PAHs（即，菲苯，3-甲基苯蒽丁烯，3,6-二甲基苯蒽蒽（36dmphe），芘和1-甲基戊烯（1MP）），是一种已知的研究了PAHS的降解。为了评估代谢产物的毒性电位，通过高效液相色谱分离含有36dmphe代谢物和1MP的代谢物的反应混合物，并评估其对富有叶氏菌的发光抑制的影响。尽管未观察到在其溶解度水平下36dmphe和1mp的发光抑制，但在其母体分子的溶解度极限下在其代谢物级分中观察到抑制。这表明初始生物转化增加了烷基化PAHs的毒性，因为代谢物的溶解度和/或固有的毒性增加。代谢物级分的定性分析表明甲基的单氧化是36dmphe和1mp的主要代谢途径。

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