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首页> 外文期刊>International journal of hyperthermia: The official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group >Advanced patient-specific hyperthermia treatment planning
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Advanced patient-specific hyperthermia treatment planning

机译：先进的患者特异性热疗治疗计划

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Hyperthermia treatment planning (HTP) is valuable to optimize tumor heating during thermal therapy delivery. Yet, clinical hyperthermia treatment plans lack quantitative accuracy due to uncertainties in tissue properties and modeling, and report tumor absorbed power and temperature distributions which cannot be linked directly to treatment outcome. Over the last decade, considerable progress has been made to address these inaccuracies and therefore improve the reliability of hyperthermia treatment planning. Patient-specific electrical tissue conductivity derived from MR measurements has been introduced to accurately model the power deposition in the patient. Thermodynamic fluid modeling has been developed to account for the convective heat transport in fluids such as urine in the bladder. Moreover, discrete vasculature trees have been included in thermal models to account for the impact of thermally significant large blood vessels. Computationally efficient optimization strategies based on SAR and temperature distributions have been established to calculate the phase-amplitude settings that provide the best tumor thermal dose while avoiding hot spots in normal tissue. Finally, biological modeling has been developed to quantify the hyperthermic radiosensitization effect in terms of equivalent radiation dose of the combined radiotherapy and hyperthermia treatment. In this paper, we review the present status of these developments and illustrate the most relevant advanced elements within a single treatment planning example of a cervical cancer patient. The resulting advanced HTP workflow paves the way for a clinically feasible and more reliable patient-specific hyperthermia treatment planning.
机译：热疗治疗计划（HTP）有助于优化热疗疗法期间的肿瘤加热。然而，由于组织性质和建模的不确定性，临床热疗计划缺乏定量准确性，报告肿瘤吸收功率和温度分布不能直接与治疗结果相关联。在过去十年中，已经取得了相当大的进展来解决这些不准确性，从而提高热疗治疗计划的可靠性。已经引入了衍生自MR测量的患者特异性电气组织电导率，以精确地模拟患者中的功率沉积。已经开发了热力学流体建模，以考虑膀胱中尿液中的流体中的对流热传输。此外，离散脉管系统已包含在热模型中，以考虑热重要大型血管的影响。已经建立了基于SAR和温度分布的基于SAR和温度分布的计算有效的优化策略，以计算提供最佳肿瘤热量剂量的相位幅度设置，同时避免正常组织中的热点。最后，已经开发了生物学建模，以量化了相同放射疗法和热疗治疗的等效辐射剂量的高温放射敏化效应。在本文中，我们审查了这些发展的现状，并说明了宫颈癌患者的单一治疗例中最相关的先进元素。由此产生的先进的HTP工作流程为临床可行和更可靠的患者特异性热疗治疗计划铺平了道路。

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