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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >Placental damages from ultrasonic changes to histopathological findings in maturing placenta in pregnancy complicated with hypertension: an observational clinical study
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Placental damages from ultrasonic changes to histopathological findings in maturing placenta in pregnancy complicated with hypertension: an observational clinical study

机译：从超声波改变对妊娠期胎盘成熟的组织病理学发现的胎盘损害造成的造成损伤和高血压：观察临床研究

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Background: The development of mild hypertension or preeclampsia at or near term is associated with minimal maternal and neonatal morbidities. Obstetric ultrasound provides a cornerstone to other modalities used for assessing hypertensive disorders of pregnancy. Placental architecture is modified in PE and eclampsia. This study was designed to detect the placental changes in hypertensive disorders of pregnancy and correlation with ultrasonic and histopathological changes. Methods: The study group comprised of 42 patients with pregnancy complicated with hypertension with period of gestation above 20 weeks and B.P. more than 140/90 mm of Hg measured on two occasions 6 hours or more apart. The control group consists of 42 normotensive patients matched with age and parity. One ultrasonic examination was performed between 28 weeks and 34 weeks and another after 34 weeks till term. Apart from routine parameters i.e. BPD, AC, FL, Amniotic fluid index, EBW and gestational age routine placental grading were performed according to the classification proposed by Grannum and associates. To evaluate perinatal outcome following measurement were studied birth weight immediately after delivery, mode of delivery, perinatal morbidity and mortality, APGAR score, presence of fetal distress. Results: In 97.62% cases (41 out of 42) of control group showed Grade–II changes as opposed to 57.14% of cases (24 out of 42) in study group before 34 weeks. All 21 cases in study group showing Grade ‘III’ changes before 34 weeks had infarction, calcification, increased syncytial knots, fibrinoid necrosis from 95.23 to 100% of these cases showed all these changes. Only 2 cases (9.52%) showed perivascular hemorrhage having Grade ‘III’ before 34 weeks. Conclusions: Accelerated maturation of placenta in pregnancy complicated with hypertension are more common in the hypertensive group. Increased histopathological degenerative changes e.g. calcification, fibrinoid necrosis etc., are more marked even before 34 weeks of gestation in hypertensive group.
机译：背景：轻度高血压或近期术语的发展与最小母体和新生儿病症有关。产科超声提供用于评估怀孕高血压障碍的其他方式的基石。胎盘体系结构在PE和Eclampsia中修改。本研究旨在检测妊娠高血压障碍和超声和组织病理学变化的胎盘变化。方法：该研究组由42名妊娠患者复杂，高血压复杂，妊娠期以上20周和B.P.超过140/90毫米的HG在两次或更远的两次或更远的地方测量。对照组由42名与年龄和平价相匹配的42名正常患者组成。在38周和34周之间进行一个超声检查，并在34周后进行另一种术语。除了常规参数中，根据Grannum和员工提出的分类，对BPD，AC，FL，羊水指数，EBW和妊娠期常规胎盘分级进行进行。为了评估围产期结果，在递送后立即进行分娩，产卵模式，围产期发病率和死亡率，APGAR得分，胎儿窘迫的存在。结果：在97.62％（42分）的对照组中，对照组显示，II级变化，而在34周之前的研究组中的57.14％（24分）。所有21例研究组出现在34周之前的“III”的变化发生梗塞，钙化，同义性结，纤维蛋白坏死从95.23到100％的这些病例显示所有这些变化。只有2例（9.52％）显示血管出血，在34周之前具有'III'等级。结论：在高血压群体中，妊娠中胎盘的加速成熟复杂性更常见。增加组织病理学退行性变化。钙化，纤维蛋白坏死等，甚至在高血压群体妊娠34周之前更具标记。

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