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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >Recurrent miscarriage in North Indian population: a study of association of polymorphisms in genes coding for the natural killer: cell receptor natural killer group 2, member D and its ligand MHC class I chain-related protein A
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Recurrent miscarriage in North Indian population: a study of association of polymorphisms in genes coding for the natural killer: cell receptor natural killer group 2, member D and its ligand MHC class I chain-related protein A

机译：北印度人口的经常性流产：对自然杀伤剂编码基因多态性关联的研究：细胞受体天然杀伤组2，成员D及其配体MHC I类链相关蛋白A.

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Background: The objective of this present study was to investigate the possible association of natural killer group (NKG) receptors gene polymorphisms and MHC class I chain-related protein A (MICA) gene polymorphism with recurrent spontaneous abortion (RSA). Methods: Three single-nucleotide polymorphism (SNPs) in NKG2D gene (rs2255336, rs2617160 and rs2617170) and one SNP in MICA gene (MICA129) rs1051792 were assessed in 100 controls and 100 patients employing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and agarose gel electrophoresis. Results: NKG2D (rs2617160) and MICA 129 (rs1051792) variants are associated with RSA risk in North Indian women. Conclusions: The NKG2D and MICA129 gene polymorphisms may influence the success of pregnancy in North Indian women population.
机译：背景：本研究的目的是研究天然杀手组（NKG）受体基因多态性和MHC类I链相关蛋白A（MICA）基因多态性与经常性自发性流产（RSA）的可能性。方法：在100种对照组中评估了NKG2D基因的三种单核苷酸多态性（SNP）（RS2255336，RS2617160和RS2617170）和一个云母基因（MICA129）RS1051792中的一个SNP，100名采用聚合酶链反应限制片段长度多态性（PCR- RFLP）和琼脂糖凝胶电泳。结果：NKG2D（RS2617160）和云母129（RS1051792）变体与北印度女性的RSA风险有关。结论：NKG2D和MICA129基因多态性可能影响北印度女性患者怀孕的成功。

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