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首页> 外文期刊>International Journal of Nanomedicine >Biomimetic synthesis of antimicrobial silver nanoparticles using in vitro-propagated plantlets of a medicinally important endangered species: Phlomis bracteosa
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Biomimetic synthesis of antimicrobial silver nanoparticles using in vitro-propagated plantlets of a medicinally important endangered species: Phlomis bracteosa

机译：抗微生物银纳米粒子的仿生合成使用药物重要的濒危物种的体外繁殖的植株：磷灰石苞片

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摘要

In vitro-derived cultures of plants offer a great potential for rapid biosynthesis of chemical-free antimicrobial silver nanoparticles (AgNPs) by enhancing their phytochemical reducing potential. Here, we developed an efficient protocol for in vitro micropropagation of a high-value endangered medicinal plant species, Phlomis bracteosa , in order to explore its biogenic potential in biomimetic synthesis of antimicrobial AgNPs. Murashige and Skoog medium supplemented with 2.0 mg/L thidiazuron was found to be more efficient in inducing optimum in vitro shoot regeneration (78%±4.09%), and 2.0 mg/L indole-3-butyric acid was used for maximum root induction (86%±4.457%). Antimicrobial AgNPs were successfully synthesized by using aqueous extract (rich in total phenolics and flavonoids content) of in vitro derived plantlets of P. bracteosa. Ultraviolet–visible spectroscopy of synthesized AgNPs showed characteristic surface plasmon band in the range of 420–429 nm. The crystallinity, size, and shape of the AgNPs were characterized by X-ray diffraction and scanning electron microscopy. Face-centered cubic AgNPs of almost uniform spherical size (22.41 nm) were synthesized within a short time (1 hour) at room temperature. Fourier-transform infrared spectroscopy revealed that the polyphenols were mainly responsible for reduction and capping of synthesized AgNPs. Energy dispersive X-ray analysis further endorsed the presence of elemental silver in synthesized AgNPs. These biosynthesized AgNPs displayed significantly higher bactericidal activity against multiple drug-resistant human pathogens. The present work highlighted the potent role of in vitro-derived plantlets of P. bracteosa for feasible biosynthesis of antimicrobial AgNPs, which can be used as nanomedicines in many biomedical applications.
机译：通过增强其植物化学还原潜力，植物的体外培养物提供了快速的无微生物银纳米粒子（AgNP）的巨大潜力。在这里，我们开发了一种高价值濒危药用植物物种的体外微扑发的有效方案，以探讨其仿生合成抗微生物agnps的生物潜力。弥补含有2.0mg / L的墨丘和Skoog培养基，在诱导最佳体外拍摄再生（78％±4.09％）和2.0mg / L吲哚-3-丁酸的最大诱导中进行更有效，用于最大根诱导（ 86％±4.457％）。通过使用P. Bracteosa的体外衍生的小植物的含水提取物（富含总酚类和黄酮类）的水性提取物（富含总酚类和黄酮类）的水性提取物成功合成抗微生物脂肪。合成agnps的紫外线可见光谱显示在420-429nm范围内的特征表面等离子体带。通过X射线衍射和扫描电子显微镜表征AgNP的结晶度，尺寸和形状。在室温下在短时间（1小时）内合成面向均匀的球形大小（22.41nm）的立方体AgNP。傅立叶变换红外光谱显示，多酚主要负责减少合成agnps的减少和封顶。能量分散X射线分析进一步介绍了合成的AgNP中的元素银的存在。这些生物合成的agnps针对多种耐药性人类病原体显示出显着更高的杀菌活性。本作本作突出了在抗微生物AgNP的可行生物合成的抗苞片中的体外衍生的植物的高效作用，其可以用作许多生物医学应用中的纳米喂水。

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