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首页> 外文期刊>International Journal of Nanomedicine >The generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles
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The generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles

机译：在类似于大气粒子的空气动力学尺寸范围内从散装源产生柴油排气​​粒子气溶胶

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Abstract: The influence of diesel exhaust particles (DEP) on the lungs and heart is currently a topic of great interest in inhalation toxicology. Epidemiological data and animal studies have implicated airborne particulate matter and DEP in increased morbidity and mortality due to a number of cardiopulmonary diseases including asthma, chronic obstructive pulmonary disorder, and lung cancer. The pathogeneses of these diseases are being studied using animal models and cell culture techniques. Real-time exposures to freshly combusted diesel fuel are complex and require significant infrastructure including engine operations, dilution air, and monitoring and control of gases. A method of generating DEP aerosols from a bulk source in an aerodynamic size range similar to atmospheric DEP would be a desirable and useful alternative. Metered dose inhaler technology was adopted to generate aerosols from suspensions of DEP in the propellant hydrofluoroalkane 134a. Inertial impaction data indicated that the particle size distributions of the generated aerosols were trimodal, with count median aerodynamic diameters less than 100 nm. Scanning electron microscopy of deposited particles showed tightly aggregated particles, as would be expected from an evaporative process. Chemical analysis indicated that there were no major changes in the mass proportion of 2 specific aromatic hydrocarbons (benzo[a]pyrene and benzo[k]fluoranthene) in the particles resulting from the aerosolization process.
机译：摘要：柴油机排气粒子（DEP）对肺部和心脏的影响是目前对吸入毒理学感兴趣的话题。流行病学数据和动物研究由于许多心肺疾病，包括哮喘，慢性阻塞性肺疾病和肺癌，含有含有空气传播的颗粒物和DEP的发病率和死亡率增加。使用动物模型和细胞培养技术研究这些疾病的病因。对新鲜燃烧的柴油燃料的实时暴露是复杂的，并且需要显着的基础设施，包括发动机操作，稀释空气和气体的监测和控制。一种从散装源在空气动力学尺寸范围内产生DEP气溶胶的方法，类似于大气DEP是一种理想的和有用的替代品。采用计量剂量吸入器技术在推进剂氢氟烷烃134a中产生从DEP的悬浮液中产生气溶胶。惯性剥离数据表明，所产生的气溶胶的粒度分布是Trimodal，计数中值空气动力学直径小于100nm。沉积颗粒的扫描电子显微镜显示出紧密聚集的颗粒，如蒸发过程所期望的那样。化学分析表明，由雾化过程产生的颗粒中的2个特异性芳烃（苯并[a]芘和苯并[k]荧蒽丁烯）没有重大变化。

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