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首页> 外文期刊>International Journal of Nanomedicine >Virucidal Action Against Avian Influenza H5N1 Virus and Immunomodulatory Effects of Nanoformulations Consisting of Mesoporous Silica Nanoparticles Loaded with Natural Prodrugs
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Virucidal Action Against Avian Influenza H5N1 Virus and Immunomodulatory Effects of Nanoformulations Consisting of Mesoporous Silica Nanoparticles Loaded with Natural Prodrugs

机译：对禽流感H5N1病毒和免疫调节作用的植物学作用和纳米型纳米型纳米型纳米粒细胞的免疫调节作用，由天然产物负载

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Background: Combating infectious diseases caused by influenza virus is a major challenge due to its resistance to available drugs and vaccines, side effects, and cost of treatment. Nanomedicines are being developed to allow targeted delivery of drugs to attack specific cells or viruses. Materials and Methods: In this study, mesoporous silica nanoparticles (MSNs) functionalized with amino groups and loaded with natural prodrugs of shikimic acid (SH), quercetin (QR) or both were explored as a novel antiviral nanoformulations targeting the highly pathogenic avian influenza H5N1 virus. Also, the immunomodulatory effects were investigated in vitro tests and anti-inflammatory activity was determined in vivo using the acute carrageenan-induced paw edema rat model. Results: Prodrugs alone or the MSNs displayed weaker antiviral effects as evidenced by virus titers and plaque formation compared to nanoformulations. The MSNs-NH2-SH and MSNs-NH2-SH-QR2 nanoformulations displayed a strong virucidal by inactivating the H5N1 virus. They induced also strong immunomodulatory effects: they inhibited cytokines (TNF-α, IL-1β) and nitric oxide production by approximately 50% for MSNs-NH2-SH-QR2 (containing both SH and QR). Remarkable anti-inflammatory effects were observed during in vivo tests in an acute carrageenan-induced rat model. Conclusion: Our preliminary findings show the potential of nanotechnology for the application of natural prodrug substances to produce a novel safe, effective, and affordable antiviral drug.
机译：背景：根据其对可用药物和疫苗，副作用和治疗成本，调用流感病毒引起的传染病是一个重大挑战。正在开发纳米胺的纳米海内西森林以允许有针对性的递送药物来攻击特定的细胞或病毒。材料和方法：在本研究中，用氨基官能化并用氨基酸（SH）的天然前药官能化的中孔二氧化硅纳米颗粒（MSN）被探索为靶向高致病性禽流感H5N1的新型抗病毒纳米粉末病毒。此外，在体外测试中研究了免疫调节效应，并且使用急性角叉菜胶诱导的爪子水肿大鼠模型在体内测定抗炎活性。结果：单独的前药或MSNS显示出较弱的抗病毒效果，与纳米族种质相比病毒滴度和斑块形成所证明的。 MSNS-NH2-SH和MSNS-NH2-SH-QR2纳米型纳米型通过灭活H5N1病毒显示出强烈的棘手。它们诱导了强大的免疫调节作用：它们抑制了MSNS-NH2-SH-QR2的细胞因子（TNF-α，IL-1β）和一氧化氮产生约50％（含有SH和QR）。在急性角叉菜胶诱导的大鼠模型中体内试验期间观察到显着的抗炎作用。结论：我们的初步调查结果显示了纳米技术应用于应用天然前药物质以产生新型安全，有效和实惠的抗病毒药物的潜力。

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