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首页> 外文期刊>International Journal of Surgical Oncology >Outcome of Cervical Lymph Nodes Dissection for Thyroid Cancer with Nodal Metastases: A Southeast Asian 3-Year Experience
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Outcome of Cervical Lymph Nodes Dissection for Thyroid Cancer with Nodal Metastases: A Southeast Asian 3-Year Experience

机译：宫颈淋巴结的结果对甲状腺癌进行髓淋巴结瘤，核糖转移：东南亚3年的经验

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Introduction. Therapeutic nodal dissection is still the mainstay of treatment for patients with lymph node metastases in many centres. The local data, however, on the outcome of therapeutic LND remains limited. Hence, this study aims to inform practice by presenting the outcomes of LND for thyroid cancer patients and our experience in a tertiary referral centre. Methods. This is a single-centre retrospective observational study in a Malaysian tertiary endocrine surgery referral centre. Patients who underwent total thyroidectomy with lymph node dissection between years 2013 and 2015 were included and electronic medical records over a 3-year follow-up period were reviewed. The outcomes of different lymph node dissection (LND), including central neck dissection, lateral neck dissection, or both, were compared. Results. Of the 43 subjects included, 28 (65.1%) had Stage IV cancer. Among the 43 subjects included, 8 underwent central LND, and 15 had lateral LND while the remaining 20 had dissection of both lateral and central lymph nodes. Locoregional recurrence was found in 16 (37.2%) of our subjects included, with no statistical difference between the central (2/8), lateral (7/15), and both (7/20). Postoperative hypocalcaemia occurred in 7 (16.3%) patients, and vocal cord palsy occurred in 5 (11.6%), whereas 9 patients (20.9%) required reoperation. Death occurred in 4 of our patients. Conclusion. High recurrence and reoperative rates were observed in our centre. While the routine prophylactic LND remains controversial, high risk patients may be considered for prophylactic LND. The long-term risk and benefit of prophylactic LND with individualised patient selection in the local setting deserve further studies.
机译：介绍。治疗性节点解剖仍然是许多中心淋巴结转移患者治疗的主干。然而，局部数据仍然是治疗LND的结果仍然有限。因此，本研究旨在通过向甲状腺癌患者提供LND的结果以及我们在第三节推荐中心的经验来告知实践。方法。这是马来西亚三级内分泌手术转诊中心的单中心回顾性观察研究。在2013年和2015年间接受淋巴结解剖总甲状腺切除术的患者，并审查了3年后续期间的电子医疗记录。比较了不同淋巴结解剖（LND）的结果，包括中央颈部剖解，侧颈部分布或两者。结果。在包含的43个受试者中，28例（65.1％）具有阶段IV癌症。在包含的43个受试者中，8个受试者，8个中央LND和15个具有横向LND，而剩余的20具有横向和中央淋巴结的解剖。在包含的16个（37.2％）的受试者中发现了型型转发，中央（2/8），外侧（7/15）和两者（7/20）之间没有统计学差异。术后低钙血症发生在7例（16.3％）患者中发生，并且5例（11.6％）发生了声带麻痹，而9名患者（20.9％）需要重新进食。死亡发生在我们的4名患者中。结论。在我们的中心观察到高复发和可逆性率。虽然常规预防性LND仍然存在争议，但可能会考虑高风险患者用于预防性LND。局部环境中具有个性化患者选择的预防性LND的长期风险和益处应得到进一步的研究。

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