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首页> 外文期刊>International Journal of Surgical Oncology >Soft Tissue Sarcomas of the Thoracic Wall: More Prone to Higher Mortality, and Local Recurrence—A Single Institution Long-Term Follow-up Study
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Soft Tissue Sarcomas of the Thoracic Wall: More Prone to Higher Mortality, and Local Recurrence—A Single Institution Long-Term Follow-up Study

机译：胸壁的软组织肉瘤：更容易出现更高的死亡率，以及局部复发 - 单一机构长期随访研究

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Objectives. This study aims to assess the impact of surgical margin and malignancy grade on overall survival (OS) and local recurrence free rate (LRFR) for soft tissue sarcomas (STS) of the thoracic wall. Methods. This retrospective cohort study identified 88 patients, diagnosed and treated surgically for a nonmetastatic STS located in the thoracic wall between 1995 and 2013, using the population based and validated Aarhus Sarcoma Registry and Danish Sarcoma Registry. The Kaplan-Meier method was used to estimate OS and LRFR. Multivariate Cox analyses were used to determine prognostic factors for OS and LRFR. Results. The 5-year OS was 55% (95% confidence interval (CI): 0.44-0.65) and 5-year LRFR was 77% (95% CI: 0.67-0.85). High malignancy grade and intralesional/marginal resection were identified as negative predictors for OS. High grade was the only prognostic factor associated with a lower LRFR. Conclusions. In this large, single institution, study tumor grade was the key predictor for OS and LRFR. Surgical margin only statistically significantly influenced mortality, not local recurrence.
机译：目标。本研究旨在评估手术边缘和恶性等级对胸壁软组织肉瘤（STS）的整体存活率（OS）和局部复发自由速率（LRFR）的影响。方法。这种回顾性队列研究确定了88名患者，用于在1995年至2013年间位于胸壁的非容性STS，使用基于人口和验证的Aarhus Sarcoma登记和丹麦萨尔康纳登记处进行诊断和治疗。 Kaplan-Meier方法用于估计OS和LRFR。多元COX分析用于确定OS和LRFR的预后因素。结果。 5年的OS为55％（95％置信区间（CI）：0.44-0.65）和5年LRF为77％（95％CI：0.67-0.85）。鉴定高恶性级和体内/边缘切除作为OS的阴性预测因子。高品位是与下层LRF相关的唯一预后因子。结论。在这个大型单一机构中，研究肿瘤等级是OS和LRFR的关键预测因子。手术边缘只有统计学意义地影响死亡率，而不是局部复发。

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