...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Surgical Oncology >The Effect of Lymph Nodes’ Histologic Response on Survival Outcomes in Moroccan Patients with Rectal Cancer
【24h】

The Effect of Lymph Nodes’ Histologic Response on Survival Outcomes in Moroccan Patients with Rectal Cancer

机译：淋巴结对直肠癌患者患者存活结果的影响

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Prognosis for patients with locally advanced rectal cancer remains controversial. The purpose of this study was to elucidate possible association between therapeutic effect on lymph nodes (LNs) and patient prognosis. Overall, 149 patients with rectal cancer received preoperative radiotherapy in concomitance with chemotherapy or exclusive radiotherapy before rectal excision. Microscopic examination of formalin-fixed lymph nodes was assessed for therapeutic effect. The establishment of groups combined reaction tissue types of fibrosis, colloid, and necrosis after neoadjuvant treatment was assigned. The average age was 56.38 years, ranged between 22 and 88 years, 53% were female, and 47% were men, with a sex ratio of 1?:?12. In the present study, we noticed that after a median follow-up time of 40.67 months (0–83; SD: 21.1), overall survival was statistically significant depending on age groups. Kaplan–Meier analysis showed significant differences in the rate of patients with an age under 65 years (70.64%) versus those with an age over 85 years (36.5%) (p0.001). Also, the OS was statistically significant depending on therapeutic effect groups composed of 0TE (No Therapeutic effect), C+ (presence of only colloidal effect), F+ (presence of only fibrosis tissue), and ME+ (mixture of 2 or 3 types of therapeutic effect) group. Indeed, we observed a significantly higher OS rate in the ME?+?group (86%) compared with the OS rate of LNs group with no therapeutic effect (57%) (p=0.028). Additionally, there was a significant association between the presence of fibrosis on LNs and an extended delay of more than 8 weeks to neoadjuvant treatment completion and surgery. Our study indicates that the best patient prognosis could be predicted based on tumor presenting a best pathologic effect on lymph nodes, and that delaying surgery for more than 8 weeks to neoadjuvant treatment completion improves therapeutic response on LNs.
机译：局部晚期直肠癌患者的预后仍然存在争议。本研究的目的是阐明治疗淋巴结（LNS）和患者预后的治疗效果之间的可能关联。总体而言，149例直肠癌患者接受术前放疗，同时进行化疗或独家放疗前的直肠切除。评估治疗效果的福尔马林固定淋巴结的显微镜检查。分配了群组组合反应组织类型的纤维化，胶体和坏死后进行新辅助治疗后的坏死。平均年龄为56.38岁，在22至88岁之间，53％是女性，47％是男性，性别比例为1？：？12。在本研究中，我们注意到，在中位后续时间为40.67个月（0-83; SD：21.1）后，总存活率根据年龄组统计学意义。 Kaplan-Meier分析显示出65岁以下患者（70.64％）的患者患者的差异，而年龄超过85岁（36.5％）（p <0.001）。此外，根据由0TE（无治疗效果），C +（仅存在胶体效应），F +（仅存在仅存在纤维化组织）的治疗效果组，以及ME +（2种或3种或3种治疗的混合物）的治疗效果组有统计学意义效果）组。实际上，我们观察到ME中的OS率明显较高？+？组（86％）与LNS组的OS率没有治疗效果（57％）（P = 0.028）。此外，LNS对纤维化的存在与未延长延迟的腹膜延长到Neoadjuvant治疗完成和手术之间存在显着关联。我们的研究表明，最佳患者预后可以基于肿瘤呈现对淋巴结的最佳病理学作用，并且延迟手术超过8周的新辅助治疗完成改善了对LNS的治疗反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号