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首页> 外文期刊>International Journal of Surgical Oncology >Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study
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Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study

机译：肛管腺癌的临床病理特征和结果：基于人群的研究

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Background. Anal canal adenocarcinoma (AA) is an uncommon tumor of the gastrointestinal tract. We seek to provide a detailed description of the incidence, demographics, and outcome of this rare tumor in the United States. Methods. The data on anal canal adenocarcinoma from SEER Program, between 1973–2015, were extracted. We analyzed the incidence rates by demographics and tumor characteristics, followed by analysis of its impact on survival. Results. The incidence of AA increased initially by 4.03% yearly from 1973 to 1985 but had a modest decline of 0.32% annually thereafter. The mean age for diagnosis of AA was 68.12?±?14.02 years. Males outnumbered females by 54.8 to 45.2%. Tumors were mostly localized on presentation (44.4%) and moderately differentiated (41.1%). Age generally correlated with poor overall cancer survival. However, young patients (age 40 years) also showed poor long-term survival. Patients with localized disease and well-differentiated tumors showed better survival outcomes. Surgical intervention improved survival significantly as compared to patients who did not (116.7 months vs 42.7 months, p0.01). Conclusions. Anal canal adenocarcinoma demonstrated a poor bimodal cancer-free survival in both younger and older patient groups. Surgery significantly improves odds of survival and should be offered to patients amenable to intervention.
机译：背景。肛管腺癌（AA）是胃肠道罕见的肿瘤。我们寻求详细描述在美国这种罕见肿瘤的发病率，人口统计学和结果。方法。提取来自SEER计划的肛管腺癌数据，提取1973 - 2015年间。我们通过人口统计和肿瘤特征分析了发病率，然后分析了其对生存的影响。结果。 AA的发病率最初每年从1973年到1985年的4.03％增加，但此后每年均下降0.32％。诊断AA的平均年龄是68.12？±14.02岁。男性数量超过54.8％至45.2％。肿瘤主要是呈现呈列（44.4％）和中度分化（41.1％）。年龄通常与整体癌症生存率差相关。然而，年轻患者（年龄<40岁）也表现出差的长期存活。局部疾病和分化良好肿瘤的患者表现出更好的生存结果。与未（116.7个月与42.7个月，P <0.01）相比，手术干预显着提高生存率。结论。肛管腺癌在较年轻人和较老的患者群体中表现出较差的双峰抗癌生存率。手术显着提高了存活的几率，并且应该向患者提供干预的患者。

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