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Clinical experience with fondaparinux in antiaggregate patients undergoing total hip and knee arthroplasty

机译:在持续臀部和膝关节形成术中的抗凝聚患者中Fongaparinux的临床经验

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Patients undergoing total hip arthroplasty or total knee arthroplasty have a high risk for post-operative venous thromboembolism. The current study addressed the use of fondaparinux post-operatively in 556 patients with antiplatelet therapy in order to prevent deep vein thrombosis as well as demonstrate efficacy in preventing arterial thrombotic events. Results provided evidence for a safe and effective prophylaxis strategy, involving the change from low molecular weight heparin pre-operatively to fondaparinux postoperatively. Also, fondaparinux proved effective as a unique post-operative therapy in the prevention of venous thromboembolism with no adverse effects, such as major bleeding or arterial thrombosis in patients with pre-operative antiplatelet therapy.
机译:接受髋关节关节成形术或全膝关节成形术的患者具有高术后静脉血栓栓塞风险。目前的研究涉及在556例抗血小板治疗患者中可操作地使用Fondaparinux,以防止深静脉血栓形成以及证明预防动脉血栓形成事件的疗效。结果为安全有效的预防策略提供了证据,术后涉及从低分子量肝素的变化术后前往Fordaparinux。此外,Fordaparinux在预防静脉血栓栓塞中的独特术后治疗方案被证明是有效的,例如患有术前抗血小板治疗的主要出血或动脉血栓形成。

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