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首页> 外文期刊>Italian Journal of Medicine >Cytokine storm and colchicine potential role in fighting SARS-CoV-2 pneumonia
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Cytokine storm and colchicine potential role in fighting SARS-CoV-2 pneumonia

机译：Cytokine风暴和血小藻素在战斗中的潜在作用在战斗中SARS-COV-2肺炎

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摘要

For some patients with SARS-CoV-2, the worst clinical damage is not caused by the virus itself, but by an overactive inflammatory state. In fact, in some people the immune system goes into overdrive and launches a large-scale assault on the tissue known as cytokine storm. This excessive inflammatory/immune reaction can damage tissue and eventually kill people. Evidence shows that blocking such cytokine storms can be effective and trials are under way to test drugs that act by reducing cytokine response, such as tocilizumab and sarilumab which bind interleukin 6 (IL-6), or anakinra which is the interleukin 1 receptor antagonist (IL-1). However, other drugs that block the cytokine cascade can also be considered. In this article we describe the scientific and molecular motivation for the use of drugs that act by modulating the hyperactive inflammatory system in severe patients suffering from SARS-CoV-2, considering in particular an old drug that has been in use for many years for other therapeutic indications such as colchicine, and that could be favorable to its use, with low cost and good tolerability.
机译：对于一些SARS-COV-2患者，最糟糕的临床损伤不是由病毒本身引起的，而是通过过度活跃的炎症状态引起。事实上，在某些人中，免疫系统进入过驱动，并在称为细胞因子风暴的组织上发动大规模攻击。这种过度的炎症/免疫反应可以损伤组织并最终杀死人。证据表明，阻断这种细胞因子风暴可以是有效的，并且正在进行试验，以通过还原细胞因子反应来试验，例如与白细胞介素6（IL-6），或者是白细胞介素1受体拮抗剂（ IL-1）。然而，也可以考虑阻断细胞因子级联的其他药物。在本文中，我们描述了通过调节患有SARS-COV-2的严重患者的多动炎症系统来使用药物的科学和分子动机，特别是考虑到其他旧药物对他人多年来一直使用的旧药物治疗适应症如血清曲霉，并且可能有利于其使用，具有低成本和良好的耐受性。

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