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首页> 外文期刊>Italian Journal of Medicine >Thrombophilias: therapeutic employment of direct oral anticoagulants in venous hypercoagulable states
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Thrombophilias: therapeutic employment of direct oral anticoagulants in venous hypercoagulable states

机译：血栓形成：在静脉高凝状态下直接口服抗凝血剂的治疗就业

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摘要

Thrombophilia or hypercoagulable state is a predisposition to form clots. Thrombophilia can be inherited or acquired, and prevalently involves venous vessels. Inherited thrombophilia consists of congenital conditions, as methylenetetrahydrofolate reductase polymorphism, Factor V Leiden and prothrombin gene mutations, natural anticoagulant deficiencies, high level of factor VIII, or dysfibrinogenemia. These congenital disorders can be responsible for venous thromboembolism, particularly deep venous thrombosis, pulmonary embolism, and, less frequently, mesenteric veins thrombosis, kidneys’ veins thrombosis or retinal vein occlusion. Acquired thrombophilia can be associated both with venous and arterial thrombosis and may be caused by antiphospholipid syndrome, aging, some malignancies, oral contraceptive use, heparin-induced thrombocytopenia, and human immunodeficiency virus. Antiplatelets’ drugs are employed in arterial thrombosis, while, heparins/oral vitamin K antagonists are indicated for acute and long-term anticoagulation. However, new oral anticoagulants can be usefully used for venous thromboembolic events. Recent experiences demonstrated that their employment is useful in some thrombophilias only, whereas other investigations are requested to evaluate their use in all hypercoagulable disorders.
机译：血栓形成或高凝状态是形成凝块的易感性。血栓形成可以继承或获得，并普遍涉及静脉血管。遗传性血栓性包括先天性条件，作为亚甲基四氢呋喃还原酶多态性，因子v赖恩和凝血酶原基因突变，天然抗凝剂缺陷，高水平的因子VIII或脱近藻血症。这些先天性疾病可以负责静脉血栓栓塞，特别是深静脉血栓形成，肺栓塞，较少频繁，肠系膜血栓形成，肾脏静脉血栓形成或视网膜静脉闭塞。获得的血栓性血栓形成可以与静脉和动脉血栓形成有关，并且可能是由抗磷脂综合征，衰老，一些恶性肿瘤，口服避孕药，肝素诱导的血小阴癣和人免疫缺陷病毒引起的。 Antiplatelets的药物在动脉血栓形成中使用，而肝素/口服维生素K拮抗剂被指示用于急性和长期抗凝。然而，新的口腔抗凝血剂可以用来用于静脉血栓栓塞事件。最近的经验表明，他们的就业仅适用于某些血栓药磷脂磷，而请求其他调查评估其在所有超可凝固障碍中的用途。

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