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首页> 外文期刊>Iranian Journal of Toxicology >Morphology, Histopathology and Hematology as Biomarkers of Cadmium Toxicity in Field Rats
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Morphology, Histopathology and Hematology as Biomarkers of Cadmium Toxicity in Field Rats

机译：野外大鼠镉毒性生物标志物的形态学，组织病理学和血液学

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Background: Cadmium is known as a unique heavy metal compared to others, due to its long half-life, low discharge from the body, toxicity at low concentrations and accumulation in tissues. Methods: The effects of chronic and acute Cadmium (Cd) exposure were investigated on the morphology and histopathology of 24 field rats (Millardia meltada). The rats were divided into two groups of 12 each, then sub-divided into: one control and two treatment sub-groups with Cd in the feed or water. The treatment subgroups received either 15mg/kg (low) or 30mg/kg (high) Cd concentration in the feed.? Results: Hemorrhagic spots and fibrosis were observed in the liver of Cd treated rats compared to the controls. Also, necrosis, dilation, and calcinosis occurred in the renal tubules of the treatment groups compared to the controls. The levels of hemoglobin, red and white blood cells, hematocrit, and mean corpuscular hemoglobin were reduced, while mean corpuscular volume and hemoglobin concentrations were increased. Conclusion: This study reports the morphological, pathological and hematological abnormalities in the blood, liver and kidneys of rats due to Cd toxicity, which may be considered as the biomarkers of cadmium toxicity in other experimental mammals.
机译：背景：与其他人相比，镉被称为独特的重金属，由于其长半衰期，从身体的低排出，毒性低浓度和组织中的积累。方法：研究了慢性和急性镉（CD）暴露的影响，对24个野外大鼠的形态和组织病理学（Millardia Meltada）进行了研究。将大鼠分成两组，然后将其分为：一种对照和两组用CD在饲料或水中的治疗子组。治疗亚组在饲料中接受15mg / kg（低）或30mg / kg（高）Cd浓度。？结果：与对照相比，在CD处理大鼠的肝脏中观察出血斑和纤维化。此外，与对照相比，治疗组的肾小管中发生坏死，扩张和钙化。血红蛋白，红色和白细胞，血细胞比容和平均碎石血红蛋白的水平降低，而平均粒状体积和血红蛋白浓度增加。结论：本研究报告了由于CD毒性引起的血液，血液，血液，肝脏和肾脏的形态学，病理和血液异常，其可被认为是其他实验哺乳动物中镉毒性的生物标志物。

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