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首页> 外文期刊>Einstein (So Paulo) >Electrocardiographic changes in spondyloarthritis and use of anti-TNF-α drugs: a retrospective study with 100 patients
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Electrocardiographic changes in spondyloarthritis and use of anti-TNF-α drugs: a retrospective study with 100 patients

机译：脊椎关节炎的心电图变化和抗TNF-α药物的使用：100名患者的回顾性研究

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Objective To investigate the prevalence of electrocardiographic changes in patients with spondyloarthritis and to correlate these changes with use of anti-tumor necrosis factor-alpha (TNF-α) drugs and HLA-B27 positivity. Methods Retrospective study including 100 patients diagnosed with spondyloarthritis according to Assessment of SpondyloArthritis International Society (ASAS) criteria and 50 controls. Epidemiological and clinical features, results of inflammatory activity tests, HLA-B27 positivity, and medication use data were extracted from medical records. Disease activity was assessed using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). All participants were submitted to electrocardiogram performed using a 12-lead device; rhythm, heart rate, conduction disorders and QT interval corrected using the Bazett formula were analyzed. Results Of 100 patients with spondyloarthritis, 51 were on anti-TNF-α drugs and 49 were not. HLA-B27 was detected in 53.1% of patients in the sample. Patients with spondyloarthritis had lower heart rate (p=0.06), longer QT interval (p0.0001) and higher prevalence of right bundle branch block (p=0.014) compared to controls. Duration of disease was weakly correlated with heart rate (Rho=0.26; 95%CI: 0.06-0.44; p=0.008). The prevalence of right bundle branch block was positively correlated with HLA-B27 positivity. Use of Anti-TNF-α drugs did not interfere with electrocardiographic parameters. Conclusion Patients with spondyloarthritis had lower heart rate, longer QT interval and a higher prevalence of right bundle branch block compared to controls. HLA-B27 positivity was associated with the prevalence of right bundle branch block. Anti-TNF-α drugs had no impact on electrocardiographic findings.
机译：目的探讨脊椎炎患者心电图变化的患病率，并将这些变化与抗肿瘤坏死因子-α（TNF-α）药物和HLA-B27阳性相关。方法回顾性研究包括根据脊椎炎国际社会（ASAS）标准和50个对照的评估，诊断患有脊椎炎的100名患者。流行病学和临床特征，从病历中提取炎症活性试验结果，HLA-B27阳性和药物使用数据。使用浴巾脊柱膜疾病活动指数（Basdai）评估疾病活性。所有参与者都使用12引导装置提交给心电图;分析了使用Bazett公式进行了校正的节奏，心率，导通障碍和QT间隔。结果100例脊椎炎患者，51例抗TNF-α药物，49例不是。在样品中的53.1％的患者中检测到HLA-B27。与对照相比，脊椎炎患者具有较低的心率（P = 0.06），较长的QT间隔（P <0.0001），右束分支块的较高率较高（P = 0.014）。疾病持续时间与心率弱相关（rho = 0.26; 95％CI：0.06-0.44; p = 0.008）。右束分支块的患病率与HLA-B27阳性呈正相关。使用抗TNF-α药物不会干扰心电图参数。结论与对照相比，脊椎炎患者具有较低的心率，较长的QT间隔和右束分支块的普遍性较高。 HLA-B27阳性与右束分支块的患病率有关。抗TNF-α药物对心电图结果没有影响。

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