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首页> 外文期刊>Endoscopy International Open >Utility of autologous fibrin glue and polyglycolic acid sheet for preventing delayed bleeding associated with antithrombotic therapy after gastric ESD
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Utility of autologous fibrin glue and polyglycolic acid sheet for preventing delayed bleeding associated with antithrombotic therapy after gastric ESD

机译：自体纤维蛋白胶水和聚乙醇酸片的效用，用于防止胃肠胃肠杆菌患者患有抗血栓治疗相关的延迟出血

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Background and study aims?Delayed bleeding is one of the most serious adverse events of gastric endoscopic submucosal dissection (ESD), especially in patients taking antithrombotic therapy. This study aimed to evaluate the utility and safety of a shielding method with autologous fibrin glue and polyglycolic acid (PGA) sheets for patients undergoing gastric ESD who are receiving antithrombotic therapy. Patients and methods?One hundred twenty-three patients who were treated with gastric ESD while receiving antithrombotic therapy between December 2014 and September 2017 were enrolled in this study. Patients who received the shielding method were classified into the shielding group.?Others were classified into the conventional group.?Various clinico-pathological factors were retrospectively compared between the two groups. Results?The shielding group consisted of 38 patients, and the conventional group consisted of the remaining 85 patients. In the shielding group, the rate of continuation of antithrombotic therapy was significantly higher (68.4?% vs 41.2?%). Incidence of delayed bleeding was lower in the shielding group (2.6?%, 1/38) than in the conventional group (14.1?%, 12/85). In the propensity score-adjusted logistic regression analysis, the delayed bleeding rate in the shielding group tended to be lower than in the conventional group (P?=?0.070). Allogeneic transfusion was performed in eight patients (8/85, 9.4?%) in the conventional group and none in the shielding group (P?=?0.047). No adverse event associated with endoscopic shielding were observed in the shielding group. Conclusions?This study suggests that a shielding method with autologous fibrin glue and PGA sheet effectively prevents delayed bleeding after gastric ESD in patients receiving antithrombotic therapy.
机译：背景和研究旨在？延迟出血是胃内镜粘膜粘膜粘膜清除（ESD）最严重的不良事件之一，特别是在服用抗血栓疗法的患者中。本研究旨在评估屏蔽方法对接受抗血栓治疗的胃肠患者的自体纤维蛋白胶水和聚乙醇酸（PGA）薄膜（PGA）薄膜的实用性和安全性。患者和方法？在2014年12月至2017年12月间接受胃肠治疗的一百二十三名患者，同时患有2017年12月至2017年9月的抗血栓形成。接受屏蔽方法的患者被分类为屏蔽基团.????????????????????????????????????????????????????????????????????????????????????????????????????.结果？屏蔽组由38例患者组成，常规组由剩余的85名患者组成。在屏蔽基团中，抗血栓治疗的延续速率显着高（68.4〜4〜41.2μm）。屏蔽基团的延迟出血的发病率低于常规组（14.1〜14.1％，12/85）。在倾向调整后的逻辑回归分析中，屏蔽组中的延迟出血率趋于低于常规组（P？= 0.070）。在常规组中在八个患者（8/85,9.4〜％）中进行同种异体输血，屏蔽基团中没有（p？= 0.047）。在屏蔽基团中观察到与内窥镜屏蔽相关的不良事件。结论？该研究表明，具有自体纤维蛋白胶水和PGA片材的屏蔽方法有效地防止胃肠患者接受抗血栓治疗后的胃肠延迟出血。

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