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首页> 外文期刊>Endoscopy International Open >Predicting pathology on small bowel capsule endoscopy: a good FIT
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Predicting pathology on small bowel capsule endoscopy: a good FIT

机译：预测小肠胶囊内窥镜检查的病理学：良好

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Background and study aims?Small bowel capsule endoscopy [SBCE) has an established role in investigating suspected small bowel bleeding [SSBB). Identification of a biomarker to predict pathology would maximize utility of this valuable diagnostic modality. This study aimed to investigate if fecal immunochemical test [FIT) could predict likelihood of small bowel pathology on SBCE. Patients and methods?Patients referred for SBCE to investigate anaemia or suspected small bowel bleeding were prospectively recruited. All patients had negative upper and lower endoscopy prior to referral. A FIT?≥?45?ug?Hb/g was considered positive. SBCE was positive if a potential source of SSBB was identified. The primary endpoint was correlation between FIT and positive SBCE. Secondary endpoints were correlation between anemia and SBCE and a combination of anemia plus FIT and SBCE. Results?Fifty-one patients were included in the final study cohort. 29.4?% had a positive FIT, 33.3?% were anemic, and 25.5?% patients had significant SBCE findings. There was a statistically significant association between positive FIT and pathology on SBCE (OR 12, 95?% CI [2.8?–?51.9), P?=?0.001). Sensitivity and specificity of positive FIT in predicting SBCE findings were 69?% and 84?%, respectively. A normal Hb had an NPV of 83?% (OR 0.30, P?=?0.09). Combining Hb and FIT was statistically significant in predicting pathology on SBCE (OR 9.14, 67?% PPV, 82?% NPV, P?=?0.025). Conclusion?FIT?≥?45?ug?Hb/g is a useful tool in predicting small bowel pathology on SBCE. Use of this biomarker alone, or in combination with serum haemoglobin, has value as a screening tool and may help to better triage patients referred for SBCE.
机译：背景和研究旨在？小肠胶囊内窥镜检查[SBCE）在调查可疑的小肠出血[SSBB）方面具有既定作用。鉴定生物标志物预测病理学将最大限度地提高该有价值的诊断方式的效用。本研究旨在调查粪便免疫化学测试[适合）是否可以预测SBCE上小肠病理的可能性。患者和方法？前瞻性地招募了患者调查SBCE或疑似小肠出血的患者。在转诊之前，所有患者均有负上下内窥镜检查。适合？≥？45？UG？Hb / g被认为是阳性的。如果确定了SSBB的潜在来源，则SBCE是正的。主要终点是配合和阳性SBCE之间的相关性。次要终点是贫血和SBCE之间的相关性以及贫血加合物和SBCE的组合。结果？五十一名患者纳入最终研究队列。 29.4？％阳性合适，33.3倍为贫血，25.5岁患者具有显着的SBCE调查结果。在SBCE上的阳性拟合和病理学之间存在统计学上显着的关联（或12,95℃[2.8？ - α51.9），p？= 0.001）。阳性拟合在预测SBCE发现中的敏感性和特异性分别为69〜％和84？％。正常HB的NPV为83Ω％（或0.30，p？= 0.09）。结合Hb和Fit在预测SBCE的病理学中具有统计学意义（或9.14,67，67％PPV，82〜％NPV，P？= 0.025）。结论？适合？≥？45？UG？Hb / g是预测SBCE上的小肠病理的有用工具。单独使用这种生物标志物，或与血清血红蛋白组合使用，具有作为筛选工具的价值，并有助于更好地提及SBCE的患者。

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