• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Endoscopy International Open >Antireflux mucosectomy band in treatment of refractory gastroesophageal reflux disease: a pilot study for safety, feasibility and symptom control
【24h】

Antireflux mucosectomy band in treatment of refractory gastroesophageal reflux disease: a pilot study for safety, feasibility and symptom control

机译：Anteteflux粘膜切除术和治疗难治性胃食管反流的疾病：安全，可行性和症状控制的试验研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and study aims?Antireflux mucosectomy band ligation (ARM-b) is an endoscopic procedure that mimics a fundoplication for managing gastroesophoageal reflux disease (GERD). The aim of this study was to assess safety and feasibility of ARM-b. Patients and methods?This was a single-center study on consecutive patients operated between June 2017 and January 2019 with refractory GERD, confirmed with pH-metry and without motility disorder at high-resolution manometry. A piecemeal mucosectomy of three quarters of circumference of esophagogastric junction was performed using a band ligation system and a hexagonal snare. The primary objective was to assess procedural safety and feasibility. The secondary objective was to document the clinical improvement at 3 and 6 months based on patient satisfaction, proton pump inhibitor (PPI) intake, symptoms, and quality of life scores. Results?Twenty-onepatients (11 men) with mean age 56.9?±?14.4 years were analyzed. The technical success rate was 100?% (mean duration 35?±?11?min). Four patients (19?%) had mild adverse events: one delayed bleeding at Day 1 managed conservatively, and three dysphagia endoscopically managed. Mean follow-up was 10?±?5 months. Decrease/discontinuation of PPI intake was 76?% at 3 months and 72?% at 6 months. Improvement in mean symptoms and quality of life scores (GERD-Q and GERD-HQL) were statistically significant. One patient required laparoscopic fundoplication after ARM-b failure without complication. Conclusion?ARM-b is safe, feasible, and symptom-effective for treating refractory GERD, and it can be performed in the ambulatory setting. Further prospective studies are required to confirm these promising outcomes.
机译：背景和研究目标？抗反射粘膜切除术带连接（ARM-B）是一种内窥镜手术，用于模仿用于管理胃食肖反流疾病（GERD）的青铜精神。本研究的目的是评估ARM-B的安全性和可行性。患者和方法？这是2017年6月和2019年1月在2019年6月期间运行的单一中心研究，难治性GERD，用PH-Metry和高分辨率测压的运动障碍确认。使用带状连接系统和六边形圈套进行三分之一的食管胃部连接率的零份粘膜切除术。主要目标是评估程序安全性和可行性。二级目标是根据患者满意度，质子泵抑制剂（PPI）摄入，症状和生活质量分数来记录3和6个月的临床改善。结果？二十同龄人（11名男子），平均年龄为56.9？±14.4岁。技术成功率为100？％（平均持续时间35？±11？11？分钟）。四名患者（19？％）具有轻微的不良事件：保守的第1天进行一次延迟出血，并且三次吞咽困难地管理。平均随访时间为10？±5个月。减少/停止PPI摄入量为76〜76℃，6个月为72％。平均症状和生活质量评分的改善（GERD-Q和GERD-HQL）具有统计学意义。一名患者在手臂B破坏后需要腹腔镜基础术而不复杂。结论？ARM-B对于治疗难治性GERD是安全的，可行的和症状有效的，并且可以在动态环境中进行。需要进一步的预期研究来确认这些有希望的结果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号