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首页> 外文期刊>Endoscopy International Open >Irregularly branched microvessels as visualized by magnifying endoscopy: a reliable marker for predicting deep submucosal invasion of superficial esophageal squamous cell carcinoma
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Irregularly branched microvessels as visualized by magnifying endoscopy: a reliable marker for predicting deep submucosal invasion of superficial esophageal squamous cell carcinoma

机译：通过放大内窥镜检查的不规则分支微血管：可靠的标记，用于预测浅表性食管鳞状细胞癌的深度粘膜侵袭

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Background and study aims?Magnifying endoscopy with narrow-band imaging (M-NBI) is reported to be useful in diagnosing invasion depth of superficial esophageal squamous cell carcinoma (SCC), but accurate diagnosis of deep submucosal invasion (SM2) has remained difficult. However, we discovered that irregularly branched microvessels observed with M-NBI are detected in SM2 cancers with high prevalence. Thus, this retrospective study aimed to investigate the diagnostic performance of irregularly branched microvessels as visualized by M-NBI for predicting SM2 cancers. Patients and methods?Patients with superficial esophageal SCC lesions that were endoscopically or surgically resected at our hospital between September 2005 and December 2014 were included. Endoscopic findings by M-NBI of these lesions were presented to an experienced endoscopist who was unaware of the histopathological diagnosis and who then judged whether irregularly branched microvessels were present. Using the invasion depth according to postoperative histopathological diagnosis as the gold standard, we determined the diagnostic performance of the presence of irregularly branched microvessels as an indicator for SM2 cancers. Results?A total of 302 superficial esophageal SCC lesions (228 patients) were included in the analysis. When irregularly branched microvessels were used as an indicator of SM2 cancers, the diagnostic accuracy was 94.0?% (95?% confidence interval [CI]: 91.1–96.1?%), sensitivity was 79.4?% (95?% CI: 66.6–88.4?%), specificity was 95.9?% (95?% CI: 94.3–97.0?%), positive predictive value was 71.1?% (95?% CI: 59.6–79.1?%), and negative predictive value was 97.3?% (95% CI: 95.7–98.5?%). Conclusions?Irregularly branched microvessels may be a reliable M-NBI indicator for the diagnosis of cancers with deep submucosal invasion.
机译：背景和研究旨在释放具有窄带成像（M-NBI）的放大内窥镜检查可用于诊断肤浅鳞状细胞癌（SCC）的侵袭深度，但精确诊断深度粘膜侵袭（SM2）仍然困难。然而，我们发现在具有高普及率的SM2癌症中观察到使用M-NBI观察到的不规则分支微血管。因此，这种回顾性研究旨在研究不规则分支的微血管的诊断性能，如M-NBI可视化，以预测SM2癌症。患者和方法？2005年9月至2014年12月在我们医院内镜下或外科医疗患者的患者，患者在2005年至2014年12月期间。将这些病变的M-NBI的内窥镜发现呈现给经验丰富的内窥镜检查者，其不知道组织病理学诊断，然后判断是否存在不规则分支的微血管。根据术后组织病理学诊断用侵袭深度作为黄金标准，我们确定了不规则分支的微血管存在的诊断性能作为SM2癌症的指示。结果？分析中共有302个浅表食管SCC病变（228名患者）。当不规则支化的微血管用作SM2癌症的指示剂时，诊断精度为94.0？％（95℃置信区间[CI]：91.1-96.1〜β％），敏感性为79.4〜7℃（95〜％CI：66.6- 88.4？％），特异性为95.9？％（95〜％CI：94.3-97.0〜94.3-97.0□％），阳性预测值为71.1〜Δ％（95〜5℃：59.6-79.1〜59.6-79.1□Δ％，负预测值为97.3？ ％（95％CI：95.7-98.5？％）。结论？不规则分支的微血管可以是可靠的M-NBI指标，用于诊断具有深度粘膜侵袭的癌症。

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