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首页> 外文期刊>Endoscopy International Open >Confocal laser endomicroscopy detects colonic inflammation in patients with irritable bowel syndrome: a prospective study
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Confocal laser endomicroscopy detects colonic inflammation in patients with irritable bowel syndrome: a prospective study

机译：共聚焦激光子宫内膜检查患者肠易激综合征患者结肠炎症：预期研究

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Background and aims?Irritable bowel syndrome (IBS) is considered to be a functional disease, but recent data indicate measurable organic alterations. We aimed to determine the presence of colorectal mucosa microinflammation in vivo via probe-confocal laser endomicroscopy (pCLE) and histological evaluation in IBS patients. Methods?This was a prospective, controlled, nonrandomized single-blind diagnostic trial performed in a tertiary institution. pCLE images and targeted biopsy of each colon segment obtained during colonoscopies of IBS patients and controls were analyzed for inflammatory changes. Biopsies were classified using the Geboes scale, and the odds ratio and overall diagnostic accuracy were calculated. Results?During the 15-month study period, 37 patients were allocated to each group.?The mean age was 53.1?±?14.3 years; 64.9?% were female. Signs of colonic mucosa inflammation were evident on 65.8?% of pCLE images from IBS patients compared to 23.4?% of images from controls (OR 6.28; 4.14–9.52; P??0.001). In total, 20/37 patients had microinflammation via pCLE in ≥?3 colon segments in the IBS group, compared to 1/37 in the control group.?A Geboes score??0 was attributed to 60.8?% of biopsies from patients in the IBS group compared to 27.5?% of biopsies from the control group.?The sensitivity, specificity, positive and negative predictive values, observed and interrater agreement of pCLE-detected inflammatory changes in IBS using histology as gold standard were 76?%, 91?%, 76?%, 91?%, 86.5?%, and 66.8?%, respectively. Conclusions?Patients with IBS have a six-fold higher prevalence of colorectal mucosa microinflammation than healthy controls. pCLE might be a reliable method to detect colorectal mucosa microinflammation in IBS patients.
机译：背景和目标？肠易激综合征（IBS）被认为是功能性疾病，但近期数据表明可测量的有机改变。我们的旨在通过探针 - 共焦激光端瘤（PCE）和IBS患者中的组织学评估来确定体内结直肠粘膜微细炎症。方法是在第三机构进行的前瞻性，受控，非扫描的单盲诊断试验。分析了在IBS患者的结肠镜和对照期间获得的每种结肠段的PCE图像和靶向活组织检查，用于炎症变化。使用易燃符尺度分类活组织检查，计算差距和整体诊断准确性。结果？在15个月的研究期间，将37例患者分配给每组。平均年龄为53.1？±14.3岁; 64.9？％是女性。从IBS患者的65.8％的PCLE图像中显而易见的肠道粘膜炎症的迹象与来自对照的23.4％的图像（或6.28; 4.14-9.52; p？<0.001）。总共，20/37名患者在IBS组中通过≥3分子段患有微细炎症，与对照组的1/37相比。易培素分数？> 0归因于患者的60.8％的活组织检查在IBS组中，与对照组的27.5？％的活组织检查相比。使用组织学称为金标准的IBS检测到的敏感性，特异性，阳性和消极预测值，观察和Interrate Sation的IBS， 91？％，76〜76℃，91μm，86.5‰，分别为66.8？％。结论？IBS的患者具有比健康对照的结直肠粘膜微细炎性的六倍倍。 PCLE可能是检测IBS患者的结肠直肠粘膜微内炎症的可靠方法。

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