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首页> 外文期刊>Endoscopy International Open >Does a history of head and neck cancer affect outcome of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma?
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Does a history of head and neck cancer affect outcome of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma?

机译：头颈癌的历史是否影响了表面食管鳞状细胞癌的内镜粘膜粘膜释放的结果？

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Background and study aims?Esophageal squamous cell carcinoma (ESCC) is the most common secondary tumor in patients with head and neck squamous cell cancer (HNSCC). Currently, endoscopic submucosal dissection (ESD) is the preferred approach to manage superficial ESCC, however, it remains to be elucidated whether patients with HNSCC and early ESCC managed by ESD have different outcomes. Patients and methods?We retrospectively analyzed esophageal ESD for early ESCC from September 2009 to September 2017 and the following variables: demographics, tumor and specimen size, Paris classification, location, en bloc and R0 resection rates, overall survival (OS) and adverse events (AEs). To reduce selection bias, propensity score matching was applied to compare the results. Results?Eighty-nine ESDs were performed in 81 consecutive patients (47 with HNSCC and 34 without HNSCC). Patients with HNSCC who developed superficial ESCC were found to be younger and to refer a more frequent history of alcohol ingestion and smoking. There was no difference in lesion size, number of lesions, procedure time, en bloc resection rate, R0 resection rate, local recurrence and adverse event rate between the two groups. The histological depth of invasion for patients with HNSCC was significantly shallower before (P?=?0.016) and after (P?=?0.047) matching. The overall survival rate was similar in both groups. Conclusions?Patients with HNSCC have earlier detection of ESCC, probably due to endoscopic screening. Previous history of chemoradiation and surgery for HNSCC does not affect procedure time, AEs and OS.
机译：背景和研究旨在？食管鳞状细胞癌（ESCC）是头部鳞状细胞癌（HNSCC）患者中最常见的继发性肿瘤。目前，内窥镜粘膜解剖（ESD）是管理肤浅ESCC的首选方法，但是，仍有待患有HNSCC和ESD的早期ESCC的患者是否有不同的结果。患者和方法？我们回顾性地分析了2009年9月至2017年9月早期ESCC的食管ESD，下列变量：人口统计，肿瘤和标本大小，巴黎分类，位置，en Bloc和R0切除率，总体生存（OS）和不良事件（AES）。为了减少选择偏差，应用倾向得分匹配来比较结果。结果？81名连续患者（47例HNSCC和34没有HNSCC）进行八十九次ESD。发现患有肤浅的HNSCC的患者是年轻的，并提及更频繁的酒精摄入和吸烟史。病变大小，病变数，病例时间，en Bloc切除率，R0切除率，局部复发和两组不良事件率没有差异。 HNSCC患者的侵袭组织学深度较浅（P？= 0.016）和（P？= 0.047）匹配后。两组的整体存活率相似。结论？HNSCC患者早期检测ESCC，可能是由于内窥镜筛查。以前的HNSCC的化学历史和手术历史不会影响程序时间，AES和OES。

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