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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Infusion of N‐acetyl cysteine during hypoglycaemia in humans does not preserve the counterregulatory response to subsequent hypoglycaemia
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Infusion of N‐acetyl cysteine during hypoglycaemia in humans does not preserve the counterregulatory response to subsequent hypoglycaemia

机译：在人类的低血糖期间输注N-乙酰基半胱氨酸并不能保留对随后的低血症的反应性反应

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Aim Administration of N‐acetyl cysteine (NAC) during hypoglycaemia will preserve the counterregulatory response to subsequent hypoglycaemia in healthy humans. Methods This was a randomized double‐blind cross over study where humans were given either a 60‐minute infusion of NAC (150?mg/kg) followed by a 4‐hour infusion of NAC (50?mg/kg) or saline starting 30?minutes before the initiation of a 2‐hour hypoglycaemic (HG) clamp at 8 am . After rest at euglycaemia for ~2?hours, subjects were exposed to a 2nd HG clamp at 2 pm and discharged home in euglycaemia. They returned the following day for a 3rd HG clamp at 8 am . Results Twenty‐two subjects were enrolled. Eighteen subjects completed the entire protocol. The epinephrine response during clamp 3 (171?±?247?pg/mL) following clamp 1 NAC infusion was lower than the response during the clamp 1 NAC infusion (538?±?392?pg/mL) (clamp 3 to clamp 1 NAC: P =?.0013). The symptom response during clamp 3 (7?±?5) following clamp 1 NAC infusion was lower than the response during the clamp 1 NAC infusion (16?±?10) (clamp 3 to clamp 1 NAC: P =?.0003). Nine subjects experienced rash, pruritus or nausea during NAC infusion. Conclusion We found no difference in the hormone and symptom response to experimental hypoglycaemia measured in subjects who were administered NAC as opposed to saline the day before. This observation suggests that further development of NAC as a therapy for impaired awareness of hypoglycaemia in patients with diabetes may be unwarranted.
机译：瞄准低血糖期间N-乙酰半胱氨酸（NAC）的施用将保持对健康人类的后续低血症的反应性反应。方法这是一项随机的双盲交叉在研究中，将人类进行60分钟输注NAC（150×mg / kg），然后再输注NAC（50μg/ kg）或盐水开始30 ？在早上8点开始2小时的低血糖（Hg）夹具前的分钟。在Euglycaemia休息后〜2？小时，受试者在下午2点暴露于2ND HG钳位，并在Euglycaemia排出家。他们在凌晨8点返回第二天的第3次HG钳位。结果二十二个受试者注册。十八名受试者完成了整个协议。在夹持1 NAC输注后夹具3（171〜±247×247×247×pg / ml）期间的肾上腺素响应低于夹具1 NAC输注期间的响应（538〜±392×pg / ml）（夹持3 NAC：P =？0013）。在夹具1 NAC输注后夹持3（7？±5）期间的症状响应低于夹具1 NAC输注期间的响应（16？±10）（夹具3，以夹持1 NAC：P = 3 NAC） 。在Nac输注期间，九个受试者经历了皮疹，瘙痒或恶心。结论我们发现对在施用NAC的受试者中测量的实验性低血糖的激素和症状反应没有差异，以前与盐水相反。该观察结果表明，NAC的进一步发展为糖尿病患者对低血糖对低血糖的认识的治疗可能是无理的。

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